Massive problem with audio interface

Hi there.
I recently bought a brandnew iMac 27" Haswell i7. I encountered problems with my Focusrite Scarlett 18i8 audio interface. These are buzzing, clicking and noise immediately or after 3 minutes or so. I tried everything, re-installed the driveres several times, nothing, really nothing worked.
Then I bought an RME Babyface audio interface - and guess what? It's the same problem. I also have a massive sound noise after some minutes or the recording channel in Garage Band drops completely.
What is wrong here? I already tried using a different power plug, tried all USB ports, turned off WiFi, HDD sleep mode, etc. Nothing worked.
Do you have an idea?
I appeciate your help,
Adrian.

same problem with my imac late 2012 27" 3.2ghz i5 and the motu ultrilite. up to now i have no solution for this problem. the worst i can't use them never before. since from the first day. i attempt  everything. from re-install to fresh install. resetting the nvram and pram. formatting the hd and make a fresh install from the operating system. using balanced audio cables and so on...but same problem all time. even my technological knowledge and know how which i have as electrical engineer couldn't help me. first i was lucky to have apple care in those situations. after get back the imac from the service provider i sadly decide nothing has changed. and they would told me it runs all fine. in meantime i testing my ni audio dj8 over usb. it's similar with the ultralite because the buzzing, clicking and noise is not so extrem as it is on ultralite. but it's here.
the curios with my macbook pro and my old imac early 2008 it runs and works fine without problems. for next week i have fixed a new date by the service provider. but then with my intercace, monitors to simulate this error and i hope they find the reason. perhaps i can tell you some news or solutions next week. i'm relly curious about it.

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    com.apple.iokit.IOStorageFamily          1.7
    com.apple.driver.AppleKeyStore          28.18
    com.apple.driver.AppleACPIPlatform          1.4
    com.apple.iokit.IOPCIFamily          2.6.5
    com.apple.iokit.IOACPIFamily          1.4
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    Memory Module: BANK 1/DIMM0, 2 GB, DDR3, 1333 MHz, 0x02FE, 0x45424A3231554538424655302D444A2D4620
    Memory Module: BANK 0/DIMM1, 2 GB, DDR3, 1333 MHz, 0x802C, 0x000000000000000000000000000000000000
    Memory Module: BANK 1/DIMM1, 2 GB, DDR3, 1333 MHz, 0x802C, 0x384A53463235363634485A2D314734443120
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    USB Device: hub_device, 0x0424  (SMSC), 0x2514, 0xfa100000 / 2
    USB Device: Maxtor 3200, 0x0d49  (Maxtor), 0x3200, 0xfa120000 / 6
    USB Device: External HDD, 0x1058  (Western Digital Technologies, Inc.), 0x1003, 0xfa130000 / 5
    USB Device: BRCM2046 Hub, 0x0a5c  (Broadcom Corp.), 0x4500, 0xfa110000 / 4
    USB Device: Bluetooth USB Host Controller, apple_vendor_id, 0x8215, 0xfa111000 / 7
    USB Device: hub_device, 0x0424  (SMSC), 0x2514, 0xfd100000 / 2
    USB Device: hub_device, 0x050d  (Belkin Corporation), 0x0234, 0xfd140000 / 5
    USB Device: DataTraveler 2.0, 0x0951  (Kingston Technology Company), 0x1607, 0xfd142000 / 7
    USB Device: Basics Desktop, 0x0d49  (Maxtor), 0x7410, 0xfd143000 / 6
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    BANK 0/DIMM0:
      Size:          2 GB
      Type:          DDR3
      Speed:          1333 MHz
      Status:          OK
      Manufacturer:          0x02FE
      Part Number:          0x45424A3231554538424655302D444A2D4620
      Serial Number:          0x245317A8
    BANK 1/DIMM0:
      Size:          2 GB
      Type:          DDR3
      Speed:          1333 MHz
      Status:          OK
      Manufacturer:          0x02FE
      Part Number:          0x45424A3231554538424655302D444A2D4620
      Serial Number:          0x245317A9
    BANK 0/DIMM1:
      Size:          2 GB
      Type:          DDR3
      Speed:          1333 MHz
      Status:          OK
      Manufacturer:          0x802C
      Part Number:          0x000000000000000000000000000000000000
      Serial Number:          0xFFFFFFFF
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      Size:          2 GB
      Type:          DDR3
      Speed:          1333 MHz
      Status:          OK
      Manufacturer:          0x802C
      Part Number:          0x384A53463235363634485A2D314734443120
      Serial Number:          0xEA364A5A

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