Massive problems with nested multi-cam sequences

Question

Hey all,
I'm absolutely pulling my hair out over some issues I'm having and hope somebody out there might have an answer.  I'm creating a short interview project, including interviews of two people individually, with two separate cameras and external sound capture.  My goal is to cut between their separate answers to each question.  For each interview I created a multi-cam sequence within its own timeline.  Then, in my master sequence, I used the source monitor to pull out the specific clips from each interview sequence which I wanted to include, and assembled them into the master timeline.
I'm having two difficulties.  First, for whatever reason, I'm experiencing audio glitching when the cuts between sequence clips occur.  The glitch is like an audio "scramble," lasts about a half second, plenty of time to be distracting and detract from the whole of the project.  There are no such audio glitches present when viewing the interview sequences specifically.  I had applied effects to the audio tracks both within the interview sequences and the master sequence.  I've since disabled every effect but the problem persists, and it is still present upon rendering the master timeline.  I have absolutely no idea what to do about this.
The second issue is more general.  I've got my media cache on an internal SSD, and I'm pulling my media from an internal HDD, with Premiere Installed on a different SSD with my operating system.  The two interview sequences play back wonderfully, no delays whatsoever.  The master timeline, however, with all the clips extracted from the interview sequences, plays slow as molasses.  It takes 10-15 seconds for the play head to even start moving once I click 'play', which has made this entire process excruciatingly difficult.  Is this a known issue?  Why would my performance be so completely degraded working with nested sequences?  Isn't everything referencing the exact same files?
Ugh, long night working on this.  Thank you for any help.

Answer 1

Well, I've come up with a terrible, but comical solution for the second issue which doesn't involve reworking anything.  It turns out that, upon launching premiere, I can play the master sequence with nested multi-cam sequences a grand total of ONCE with minimal delay.  If I stop the play through, then it will take 3-4 minutes to get the sequence playing again.  Of course, the Premiere decides to hang when I try to close it after playing this master timeline, so I'm finding that I can inch my way through this project by (1) launching premiere, (2) playing the master sequence, (3) make the edits I need, (4) forcibly crash Premiere, and (5) relaunch Premiere and repeat.  It's a terrible way to work, but the project is so close to completion that I'm willing to suffer through it.
As to issue 1, I've taken each offending clip, extending the audio track one or two frames in the beginning of each clip, and then use those frames to ramp the volume up from silent to 0db.  This seems to avoid the brief moment of distortion at the beginning.  Notably I did try your suggestion by going back to the original, source audio, but I was still getting the same issue.  My work-around is the only solution I've been able to come up with.