Mavericks running slow on my MacBook

Question

Here is the EtreCheck for my system.  Any suggestions would be appreciated!
Hardware Information:
          MacBook (13-inch, Late 2009)
          MacBook - model: MacBook6,1
          1 2.26 GHz Intel Core 2 Duo CPU: 2 cores
          4 GB RAM
Video Information:
          NVIDIA GeForce 9400M - VRAM: 256 MB
Audio Plug-ins:
          BluetoothAudioPlugIn: Version: 1.0
          AirPlay: Version: 1.9
          AppleAVBAudio: Version: 2.0.0
          iSightAudio: Version: 7.7.3
System Software:
          OS X 10.9 (13A603) - Uptime: 0 days 19:7:31
Disk Information:
          Hitachi HTS545050B9SA02 disk0 : (500.11 GB)
                    EFI (disk0s1) <not mounted>: 209.7 MB
                    Macintosh HD (disk0s2) /: 499.25 GB (341.2 GB free)
                    Recovery HD (disk0s3) <not mounted>: 650 MB
          MATSHITADVD-R   UJ-898 
USB Information:
          Seagate Backup+ BK 1 TB
                    EFI (disk1s1) <not mounted>: 209.7 MB
                    Seagate Backup Plus (disk1s2) /Volumes/Seagate Backup Plus: 950.2 GB (395.42 GB free)
                    FAT VOLUME (disk1s3) /Volumes/FAT VOLUME: 49.65 GB (49.15 GB free)
          Apple Inc. Built-in iSight
          Apple Inc. BRCM2070 Hub
                    Apple Inc. Bluetooth USB Host Controller
          Apple Inc. Apple Internal Keyboard / Trackpad
FireWire Information:
Thunderbolt Information:
Kernel Extensions:
          com.logmein.driver.LogMeInSoundDriver          (1.0.2)
          com.seagate.driver.PowSecDriverCore          (5.2.3)
          com.seagate.driver.PowSecLeafDriver_10_5          (5.2.3)
          com.parallels.kext.usbconnect          (9.0
          com.parallels.kext.hypervisor          (9.0
          com.parallels.kext.hidhook          (9.0
          com.parallels.kext.netbridge          (9.0
          com.parallels.kext.vnic          (9.0
          com.parallels.filesystems.prlufs          (2010.12.28)
Problem System Launch Daemons:
          [failed] com.apple.AOSNotificationOSX.plist
          [failed] com.apple.wdhelper.plist
Problem System Launch Agents:
Launch Daemons:
          [loaded] com.adobe.fpsaud.plist
          [loaded] com.google.keystone.daemon.plist
          [not loaded] com.logmein.logmeinblanker.plist
          [loaded] com.logmein.logmeinserver.plist
          [loaded] com.macpaw.CleanMyMac2.Agent.plist
          [loaded] com.microsoft.office.licensing.helper.plist
Launch Agents:
          [loaded] com.google.keystone.agent.plist
          [loaded] com.logmein.logmeingui.plist
          [loaded] com.logmein.logmeinguiagent.plist
          [not loaded] com.logmein.logmeinguiagentatlogin.plist
          [loaded] net.culater.SIMBL.Agent.plist
User Launch Agents:
          [loaded] com.divx.agent.postinstall.plist
          [loaded] com.google.Chrome.framework.plist
          [loaded] com.macpaw.CleanMyMac2Helper.diskSpaceWatcher.plist
          [loaded] com.macpaw.CleanMyMac2Helper.scheduledScan.plist
          [loaded] com.macpaw.CleanMyMac2Helper.trashWatcher.plist
User Login Items:
          LMILaunchAgentFixer
          Google Chrome
          iTunesHelper
          Dropbox
          HPEventHandler
          HP Scheduler
3rd Party Preference Panes:
          Flash Player
          Flip4Mac WMV
          MacFUSE
          TimeMachineScheduler
Internet Plug-ins:
          CouponPrinter-FireFox.plugin
          Default Browser.plugin
          DivXBrowserPlugin.plugin
          Flash Player.plugin
          FlashPlayer-10.6.plugin
          Flip4Mac WMV Plugin.plugin
          GarminGPSControl.plugin
          Google Earth Web Plug-in.plugin
          iPhotoPhotocast.plugin
          LogMeIn.plugin
          LogMeInSafari32.plugin
          OfficeLiveBrowserPlugin.plugin
          OVSHelper.plugin
          QuickTime Plugin.plugin
          SharePointBrowserPlugin.plugin
          Silverlight.plugin
          SlingPlayer.plugin
User Internet Plug-ins:
          WebEx64.plugin
Bad Fonts:
          None
Time Machine:
          Skip System Files: NO
          Mobile backups: ON
          Auto backup: YES
          Volumes being backed up:
                    Macintosh HD: Disk size: 499.25 GB Disk used: 158.05 GB
          Destinations:
                    Seagate Backup Plus [Local] (Last used)
                    Total size: 950.2 GB
                    Total number of backups: 66
                    Oldest backup: 2013-03-21 20:25:31 +0000
                    Last backup: 2013-11-09 22:52:11 +0000
                    Size of backup disk: Adequate
                              Backup size 950.2 GB > (Disk used 158.05 GB X 3)
Top Processes by CPU:
               6%          prl_vm_app
               3%          WindowServer
               1%          EtreCheck
               1%          Finder
               1%          prl_disp_service
               1%          prl_client_app
               0%          Memory Clean
               0%          fontd
               0%          hidd
               0%          LogMeIn
Top Processes by Memory:
          307 MB             prl_vm_app
          111 MB             Google Chrome
          106 MB             com.apple.IconServicesAgent
          74 MB              Mail
          66 MB              prl_client_app
          49 MB              Dropbox
          41 MB              mds_stores
          37 MB              WindowServer
          29 MB              Memory Clean
          27 MB              Google Chrome Helper
Virtual Memory Statistics:
          218 MB             Free RAM
          835 MB             Active RAM
          628 MB             Inactive RAM
          1.78 GB            Wired RAM
          8.92 GB            Page-ins
          1.02 GB            Page-outs

Answer 1

All the usual caveats apply, backup before you modify the system, delete the items (or move them to another disk or folder if you are worried about deleting the wrong thing) but ensure the originals are gone or updated.
Use the Finders "Go menu > Go to Folder…" to open the hidden ~/Library (your users library).
Reboot for the system changes to take effect.
I'm trimming the report back to the items I think are worth looking into…
Gerald Malis wrote:
Kernel Extensions:
          com.logmein.driver.LogMeInSoundDriver          (1.0.2)
          com.seagate.driver.PowSecDriverCore          (5.2.3)
          com.seagate.driver.PowSecLeafDriver_10_5          (5.2.3)
          com.parallels.kext.usbconnect          (9.0
          com.parallels.kext.hypervisor          (9.0
          com.parallels.kext.hidhook          (9.0
          com.parallels.kext.netbridge          (9.0
          com.parallels.kext.vnic          (9.0
          com.parallels.filesystems.prlufs          (2010.12.28)
Problem System Launch Daemons:
          [failed] com.apple.AOSNotificationOSX.plist
          [failed] com.apple.wdhelper.plist
Launch Daemons:
          [loaded] com.adobe.fpsaud.plist
          [loaded] com.google.keystone.daemon.plist
          [not loaded] com.logmein.logmeinblanker.plist
          [loaded] com.logmein.logmeinserver.plist
          [loaded] com.macpaw.CleanMyMac2.Agent.plist
          [loaded] com.microsoft.office.licensing.helper.plist
Launch Agents:
          [loaded] com.google.keystone.agent.plist
          [loaded] com.logmein.logmeingui.plist
          [loaded] com.logmein.logmeinguiagent.plist
          [not loaded] com.logmein.logmeinguiagentatlogin.plist
          [loaded] net.culater.SIMBL.Agent.plist
User Launch Agents:
          [loaded] com.divx.agent.postinstall.plist
          [loaded] com.google.Chrome.framework.plist
          [loaded] com.macpaw.CleanMyMac2Helper.diskSpaceWatcher.plist
          [loaded] com.macpaw.CleanMyMac2Helper.scheduledScan.plist
          [loaded] com.macpaw.CleanMyMac2Helper.trashWatcher.plist
User Login Items:
          LMILaunchAgentFixer
          Google Chrome
          iTunesHelper
          Dropbox
          HPEventHandler
          HP Scheduler
3rd Party Preference Panes:
          Flash Player
          Flip4Mac WMV
          MacFUSE
          TimeMachineScheduler
Internet Plug-ins:
          CouponPrinter-FireFox.plugin
          Default Browser.plugin
          DivXBrowserPlugin.plugin
          Flash Player.plugin
          FlashPlayer-10.6.plugin
          Flip4Mac WMV Plugin.plugin
          GarminGPSControl.plugin
          Google Earth Web Plug-in.plugin
          iPhotoPhotocast.plugin
          LogMeIn.plugin
          LogMeInSafari32.plugin
          OfficeLiveBrowserPlugin.plugin
          OVSHelper.plugin
          QuickTime Plugin.plugin
          SharePointBrowserPlugin.plugin
          Silverlight.plugin
          SlingPlayer.plugin
Top Processes by CPU:
               6%          prl_vm_app
               3%          WindowServer
               1%          EtreCheck
               1%          Finder
               1%          prl_disp_service
               1%          prl_client_app
               0%          Memory Clean
               0%          fontd
               0%          hidd
               0%          LogMeIn
Top Processes by Memory:
          307 MB             prl_vm_app
          111 MB             Google Chrome
          106 MB             com.apple.IconServicesAgent
          74 MB              Mail
          66 MB              prl_client_app
          49 MB              Dropbox
          41 MB              mds_stores
          37 MB              WindowServer
          29 MB              Memory Clean
          27 MB              Google Chrome Helper
Virtual Memory Statistics:
          218 MB             Free RAM
          835 MB             Active RAM
          628 MB             Inactive RAM
          1.78 GB            Wired RAM
          8.92 GB            Page-ins
          1.02 GB            Page-outs
Random notes:
Your RAM has been exhausted in the 19 hours the Mac has been running -
          1.02 GB            Page-outs
You need to do less with this system or it will always be slow…
You have CleanMyMac installed -> com.macpaw.CleanMyMac2.Agent.plist, this is know to delete system files & can also cause system instability. See the cleanmymac threads if you need help deciding if you want or need it installed.
https://discussions.apple.com/search.jspa?q=cleanmymac
Personally I think it should be removed since it won't help diagnose the issues you currently have.
http://macpaw.com/support/cleanmymac/knowledgebase/how-to-uninstall-cleanmymac-2
You also have SIMBL - net.culater.SIMBL.Agent.plist, this is a 'system level hack' that can alter everything in the OS. Remove it.
http://www.culater.net/software/SIMBL/SIMBL.php
You should also delete the plugins from the folders listed on the above page.
You also have a lot of items that open during login - remove all of them to stand a fighting chance of opening the Finder & cleaning things up.
There is a very simple test to see if all the startup & background jobs are the issue - boot into safe mode.
https://support.apple.com/kb/HT1455
If the Mac suddenly appears better it is because all the third party apps are disabled. Some things won't work in safe mode - this is normal just reboot to get the features back.
'Memory Clean' is also running - you really shouldn't be 'cleaning' memory. The OS knows what code & files it needs to access, if you 'clean' them it simply will need to reload them later. It will cause more slowness than it solves.  Mavericks is designed to handle memory better than any previous Mac OS, please don't assume you can do a better job.
Clean up by following…
Kernel Extensions:
Inside /Library/Extensions/
These also load third party code, but they insert it into the 'core' of the OS. These can be safe, however you must ensure the related tools or apps are up to date, otherwise the system is basically built upon quicksand. Remove them all & see if the OS works better.
Launchd jobs: several types
LaunchAgents          - Stored in /Library/LaunchAgents
LaunchDaemons      - Stored in /Library/LaunchDaemons
User LaunchAgents  - Stored in ~/Library/LaunchAgents
These are all background jobs, they are not necessarily bad, but if they are loading old code it could be doing untold damage to the performance & stability of the entire OS. Focus on the System level jobs (the ones inside /Library - the system level) also look at 'failed' jobs.
EtreCheck gives a status on launchd jobs…
[loaded]                  - a running job
[not loaded]            - jobs that are set not to run, basically harmless, remove them unless you plan to use the associated software (if it is up to date)
[failed]                   - jobs in a crashed or unknown state, it could be forking processes or using all the system resources, remove these.
User login items:
Applications and helpers that are managed inside 'Systems Preferences > Users and groups > Login Items tab'.
These are loaded at the 'User level', consider removing all of them whilst you troubleshoot.  When you decide to re-add them ensure the software is up to date.
3rd Party Preference Panes: & Internet Plug-ins:
/Library/PreferencePanes/ and ~/Library/PreferencePanes/
/Library/Internet Plug-Ins/ and ~/Library/Internet Plug-Ins/
Once again these items all must be up to date, or remove them from your system. If the prefpanes manage additional software use the uninstaller or see the developers site for uninstall instructions.
Read the list of Internet plug-ins carefully, there are often duplicate Flash player versions that won't help stability, it's just wasted space too.
Don't forget to also update Safari's extensions in it's preferences (if you have any).
Re-run EtreCheck after cleaning up to see if items have returned (some apps will reload the background jobs when re-opened, so either update or remove the software).
If all of this seems like too much work consider erasing & reinstalling a clean copy of 10. The OS will run much better without years of old junk software trying to do too many things in the background. Just avoid installing too many utilities like CleanMyMac, SIMBL, Memory Clean - they do more harm than good IMO.