Mavericks still spinning beachballs after 6 months.

Question

It's driving me mad. Spinning beachball for even the slightest action like clicking a folder to open it (takes 5-15 seconds), fan comes on all the time, Mail app takes 5 minutes to load and slows everything down, using an application like Lightroom is now a nightmare with delays even selecting photos to view. I want my nice Mac back.
i've run EtreCheck as recommended. Does this provide any clues? Tried restarting in safe mode.Thinking my next move is to reinstall Mavericks.
EtreCheck version: 1.9.11 (43) - report generated 9 June 2014 21:59:41 BST
Hardware Information:
    MacBook Pro (15-inch, Late 2008)
    MacBook Pro - model: MacBookPro5,1
    1 2.4 GHz Intel Core 2 Duo CPU: 2 cores
    4 GB RAM
Video Information:
    NVIDIA GeForce 9400M - VRAM: 256 MB
    NVIDIA GeForce 9600M GT - VRAM: 256 MB
System Software:
    OS X 10.9.2 (13C64) - Uptime: 0 days 0:52:44
Disk Information:
    ST1000LM024 HN-M101MBB disk0 : (1 TB)
        EFI (disk0s1) <not mounted>: 209.7 MB
        Macintosh HD (disk0s2) / [Startup]: 896.48 GB (224.6 GB free)
        Recovery HD (disk0s3) <not mounted>: 650 MB
        BOOTCAMP (disk0s4) /Volumes/BOOTCAMP: 102.86 GB (20.84 GB free)
    MATSHITADVD-R   UJ-868 
USB Information:
    Apple Inc. Built-in iSight
    Apple, Inc. Apple Internal Keyboard / Trackpad
    Apple Computer, Inc. IR Receiver
    Apple Inc. BRCM2046 Hub
        Apple Inc. Bluetooth USB Host Controller
Gatekeeper:
    Mac App Store and identified developers
Kernel Extensions:
    [not loaded]    com.Cycling74.driver.Soundflower (1.4.3) Support
    [kext loaded]    com.epson.driver.EPSONProjectorUDAudio (1.30 - SDK 10.4) Support
    [not loaded]    com.mice.driver.Wireless360Controller (1.0.0d2) Support
    [not loaded]    com.mice.driver.WirelessGamingReceiver (1.0.0d2) Support
    [not loaded]    com.mice.driver.Xbox360Controller (1.0.0d8) Support
    [kext loaded]    com.rogueamoeba.HermesAudio (4.1.0) Support
    [not loaded]    com.roxio.TDIXController (1.7) Support
Startup Items:
    360ControlDaemon: Path: /Library/StartupItems/360ControlDaemon
    ProTec6: Path: /Library/StartupItems/ProTec6
    Qmaster: Path: /Library/StartupItems/Qmaster
Launch Daemons:
    [loaded]    com.adobe.fpsaud.plist Support
    [loaded]    com.adobe.SwitchBoard.plist Support
    [loaded]    com.microsoft.office.licensing.helper.plist Support
    [loaded]    com.noiseindustries.FxFactory.plist Support
    [loaded]    com.oracle.java.Helper-Tool.plist Support
    [loaded]    com.rogueamoeba.hermes.plist Support
    [failed]    net.juniper.AccessService.plist Support
    [loaded]    net.juniper.UninstallPulse.plist Support
Launch Agents:
    [not loaded]    com.adobe.AAM.Updater-1.0.plist Support
    [loaded]    com.adobe.CS4ServiceManager.plist Support
    [loaded]    com.adobe.CS5ServiceManager.plist Support
    [loaded]    com.hp.help.tocgenerator.plist Support
    [loaded]    com.oracle.java.Java-Updater.plist Support
    [failed]    net.juniper.pulsetray.plist Support
User Launch Agents:
    [loaded]    com.adobe.AAM.Updater-1.0.plist Support
    [running]    com.akamai.single-user-client.plist Support
    [running]    com.amazon.cloud-player.plist Support
    [not loaded]    com.freenet.startup.plist Support
    [loaded]    com.genieo.completer.download.plist Support
    [loaded]    com.genieo.completer.update.plist Support
    [loaded]    com.google.keystone.agent.plist Support
    [loaded]    com.macpaw.CleanMyMac.helperTool.plist Support
    [loaded]    com.macpaw.CleanMyMac.trashSizeWatcher.plist Support
    [running]    com.spotify.webhelper.plist Support
    [loaded]    com.valvesoftware.steamclean.plist Support
User Login Items:
    USB Display Agent
    Spotifree
    TuneupMyMac
    USB Display Agent
    HPEventHandler
Internet Plug-ins:
    JavaAppletPlugin: Version: Java 7 Update 51 Check version
    FlashPlayer-10.6: Version: 13.0.0.214 - SDK 10.6 Support
    Default Browser: Version: 537 - SDK 10.9
    Flash Player: Version: 13.0.0.214 - SDK 10.6 Support
    CANONiMAGEGATEWAYDL: Version: 3.1.0.2 Support
    DivXBrowserPlugin: Version: 2.0 Support
    QuickTime Plugin: Version: 7.7.3
    SharePointBrowserPlugin: Version: 14.1.0 Support
    Unity Web Player: Version: UnityPlayer version 2.6.1f3 Support
    Silverlight: Version: 5.1.20913.0 - SDK 10.6 Support
    iPhotoPhotocast: Version: 7.0
Safari Extensions:
    AdBlock: Version: 2.6.34
    My eBay Manager: Version: 3.1.0
    AllMyTube: Version: 4.3.0.0
    Flickr Original: Version: 1.3
Audio Plug-ins:
    BluetoothAudioPlugIn: Version: 1.0 - SDK 10.9
    AirPlay: Version: 2.0 - SDK 10.9
    AppleAVBAudio: Version: 203.2 - SDK 10.9
    iSightAudio: Version: 7.7.3 - SDK 10.9
iTunes Plug-ins:
    Quartz Composer Visualizer: Version: 1.4 - SDK 10.9
User iTunes Plug-ins:
    AudioScrobbler: Version: 4.0.0 - SDK 10.7 Support
User Internet Plug-ins:
    Picasa: Version: 1.0 Support
3rd Party Preference Panes:
    Akamai NetSession Preferences  Support
    DivX  Support
    Flash Player  Support
    Growl  Support
    Java  Support
    MagicPrefs  Support
    MusicManager  Support
Time Machine:
    Skip System Files: NO
    Mobile backups: OFF
    Auto backup: NO - Auto backup turned off
    Time Machine not configured!
Top Processes by CPU:
         3%    WindowServer
         2%    mds
         2%    mdworker
         0%    applet
         0%    fontd
Top Processes by Memory:
    414 MB    firefox
    147 MB    com.apple.IconServicesAgent
    86 MB    com.apple.internetaccounts
    86 MB    Dock
    61 MB    CalendarAgent
Virtual Memory Information:
    775 MB    Free RAM
    1.62 GB    Active RAM
    860 MB    Inactive RAM
    549 MB    Wired RAM
    281 MB    Page-ins
    0 B    Page-outs

Answer 1

I see two issues right away that are causing you problems. Clean My Mac and Genieo
However, I also see a lot of failed Kernel Extensions. I suspect you have a lot of older files that are still trying to run.
The forums are full of users with computers that no longer work correctly after running these so call 'cleaners' (Memory Clean, CleanMyMac, and MacKeeper). Do not install any third party so called Mac cleaning utilities. They can do harm to your Mac.
See this thread for removing Clean My Mac
https://discussions.apple.com/message/25680635#25680635
Genieo - how to remove:
http://www.thesafemac.com/art/
You have two choices.
1) try to fix by removing all the old files and repair damage done by clean my mac
Or
2) Do a clean install of Mavericks and bring over only your personal files.
If you want to prove to yourself that it would be worth while to do the clean install, we can setup a small 20 GB partition for Mavericks and you can test Mavericks out without all the baggage in your current install.