Maximum HD size for Mac Pro (2006) Dual Core 2.66GHZ

I have purchased a second hand Mac Pro which has 4 empty HD bays, I would like to put at least 1TB, perhaps 2TB in each bay for a total of between 3 to 6TB maximum storage in the empty bays, but apparently Apple only formally supports up to 2 TB of storage with four 500 GB hard drives (one in each internal bay).
Has anyone had any problems with larger than recommended HD's?

1 TB and 2 TB are fine
Disks larger than 2.2 TB:have a problem being formated with the later OSX versions:
Format large disks
That bug appeared in 10.8.4, and has not yet been fixed.
using a Disk Utility from any older Mac OS X, including the mentioned 10.6 DVD (if your Mac can boot from it) or any saved Installer DVD or thumb drive will work.
Another work-around is to move that drive to an external enclosure and Erase it there (provided your enclosure is modern enough to deal with drives over 2.2TB.
Also, some disks larger than 3 TB or so have problems with the screws retaining the disks in the sled being too long because of the extra platters in the large disks

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