MB 2.16 core 2 duo mouse not clicking

I have a USB cordless mouse hooked up to a MB C2D 2.16Mhz and the mouse will not click on anything in the top half of the window in Safari.  This makes it really hard to use Facebook.  I have tried different mice with the same problem.  It also seems intermitent. 
Any ideas?

The difference between 2.16 GHz and 2.2 GHz is of course too small to notice, but the 2.2 GHz MBP also comes with the new Santa Rosa chipset with a faster front side bus, and reviews and benchmarks have indicated that the difference, while not dramatic, is significant.
The 2.2 MBP also has a new and reportedly better video card. I don't know enough about the extent to which more RAM compensates for the otherwise inferior nature of the older card.
More important, I think, is the fact that the 15" SR MBPs come with the LED backlit screen. My spouse has the older MBP and my screen is brighter and has more even lighting. The LED also weighs less, uses less battery, needs no time to warm up to full brightness and is said to last longer without dimming over the years.
To me, the LED screen is the big reason to get the new MBP. (They're even starting to show up on Apple's refurb page; I saw one yesterday for $1699).

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