MBP + external monitor + USB mouse + iTunes = lag

Hello, I am wondering if any of you can offer a solution to my problem. When I use my mac with my external monitor and external mouse, there is a systemwide lag every 3 seconds - the display sort of pauses, briefly interrupting mouse input and video playback. When deleting a long line of text it is again apparent.
It is not the mouse, as I have tried 3 different mice with the up to date drivers and they all work fine while itunes is not open and when using the laptop's screen, which also eliminates the variable of a poor mouse surface (it is good regardless).
There is no skipping when using the laptop's screen, regardless of itunes being open or not. Also, there is no skipping at all when I boot into windows and use it with the external display.
The skipping also occurs when video is being played back via Quicktime, with iTunes closed. The same video played with VLC does not cause the issue.
I have the computer hooked up to a Samsung SyncMaster 2494HM LCD, via the apple mini DP to DVI adapter, and with a DVI-HDMI cable (this decreased the issue from when it was connected with DVI and skipped all the time).
I have tried a different user account, and the problem persists there too. I have reset my PRAM and NVRAM also.
This is quite strange; any suggestions?

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