Message saying there is no room on my HD but 345GB available

I am trying to save a simple word document but message says no room on HD. Looking at disk utility there is loads of space Help!!

Are you using Time Machine?  Is MacKeeper installed?  Both of these can adversely affect invisible space for different reasons.  MacKeeper for all intents is Malware, and should be removed with these instructions:
https://discussions.apple.com/docs/DOC-3022
Time Machine really needs a hard drive dedicated to it that is at least twice the capacity of the data stored on the original and that destination drive should only be accessed from the Finder if Time Machine's automatic backup feature is turned off.

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