Message window won't open after double-clicking message in list

When I re-launched Mail, I suddenly lost the ability to open a message by double-clicking it in the message list window. I can view the message in the preview window at the bottom of the list, but without opening the message itself, I seem to lose the ability to reply, forward, etc.
Coincidentally, in case the problem is related, I also noticed that Safari no longer opens a window after launch. Going to "File" in the menu bar and selecting "New Window" produces nothing.
Anyone have a clue about fixing these?

Read the following article for general troubleshooting and cache-cleaning procedures:
Resolving Disk, Permission, and Cache Corruption
In particular, be sure to verify/repair the startup disk (not just permissions), and to read this as well:
Side effects of System cache cleaning
In addition to the utilities mentioned there for cache cleaning, you may also consider OnyX or Cache Out X, which are free.
More specifically, this could be caused by some Launch Services cache or preferences corruption. The following article describes how to manually reset Launch Services -- the notes at the bottom of the article also provide information about the side effects of deleting each of the files involved:
Resetting Launch Services
And this is how you should proceed to reset Launch Services with OnyX, for example:
1. Quit all applications.
2. Launch OnyX and enter your administrator password.
3. Click Maintenance. In the Reset section, check LaunchServices database.
4. You may uncheck any other pre-checked options if you wish.
5. Click the Execute button.
6. Restart the computer.

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