Mixing RAM Mac Pro

Hello!
I have read the other posts about this issue but I want to make sure I understand it correctly.
Do not mix 4 & 8gb RAM with 16gb and higher RAM. That part I get, but what I want to be sure of is that I can configure the RAM as follows...
2 slots with original 4gb RAM and 2 slots with 8gb RAM
According to what I've read, this should be acceptable, correct? How much will this configuration compromise the performance as I can't afford 4-8gb ram modules? I work with a lot of large image files and usually have Lightroom & Photoshop running at the same time. Even with the 16gb I currently have, I get the force quit window popping up to tell me apps have been paused quite a bit.
Thanks for help!! Have a good one!!
Lisa Rose

Yes, that's acceptable. It won't compromise performance to put in more RAM.

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