More than one profile opens slows down machine

Hi, I have a strange problem that has only started in the last month or so.
Firstly - Mac Pro, 2008, ATY,RadeonX1900 512mb, 9mb Ram, 2 x 2TB HD, 1 x 1TB, 1 x 750, 2TB HD's are new and have fitted to improve speed as only have 10g free before and assumed that was problem, also increased Ram from 5mb to 9mb. Machine had been running very slowly but upgrades have dealt with it on the whole.
Overall speed of machine is great with single profie open, AVIs play fine and dont see the spinning wheel
The moment both profiles are logged in then AVI's keep freezing, irrespective of playing software and spinning wheel appears when trying to load web etc, these are just a few examples of slowdown. The only way I can unfreeze AVIs is to drag the mouse into the corner that I have set to show all windows, this also makes the web pages load and gets rid of spinning wheel.
Thanks for reading, hope someone can offer some ideas, otherwise I think a genius bar appointment is in order

Clone the system to your fastest drive, and partition the drive to a 300-400GB partition for the OS, and forget the rest of the drive.
Boot drive should be OS and apps and just mini home folder
all the data, media, etc should reside on other drives
some would raid0 the 2 x 2TB for a large fast media volume
Ideal in boot drive would be 120GB SSD, or for same $$ even a huge 2-3TB drive using 1/4 of its capacity.
(ps: dust on the X1900? pull it out regularly? run smcfancontrol 2.2.x to boost air flow and cooling / an ATI 5770 is a nice replacement upgrade too)
And on FBDIMMs: 4 x 2GB or 4 x 4GB are the best ideal in memory bandwidth and performance, not 6 dimms, and if you use 8 DIMMs then 8 x 2GB

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More than one profile opens slows down machine

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