Mouse and keyboard shortcuts not working

I running Firefox 3.6.12 on a Mint 10 Gnome system. Firefox has worked very well for the past month with no problems. Today the mouse quit working when trying to click on any of the pulled down menus at the top, "File, Edit, View..." it also will not work on any pull down menus on screen, address bar, stumble tools... The shortcut keys for the top menu are also not working, Alt F will not pull the file menu down. The mouse works on links and single buttons such as the stumble button or bookmark buttons. Also, right clicking does not work anywhere in Firefox, but works in other programs.
I have rebooted the system and uninstalled and reinstalled Firefox to no avail. Any help would be greatly appreciated.

I started Firefox in safe mode and everything started working as it should.
Restarted in normal mode and everything is again working, I didn't make any changes.
The theme was set at default as I have never changed it. I installed all the addons when I first got Firefox, no new ones have been added in over a month.
Does starting in safe mode reset the addons and plugins? Curious as to why starting in safe mode corrected the problem.

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