Mouse and keybord stopped working after upgrading to Mavericks.

Since upgrading from snow Leopard to Mavericks, the Apple USB keyboard and mouse nolonger work on my Mac Pro. I've tried booting in safe mode sucsessfuly, but the keyboard and mouse still don't work. Can anybody help me please?
Thanks,
Dave

Test the devices with another computer, if possible. If they work, or if you can't test, see below.
If you don't already have a current backup, back up all data, then reinstall the OS.* You don't need to erase the startup volume, and you won't need the backup unless something goes wrong. If the system was upgraded from an older version of OS X, you may need the Apple ID and password you used.
There are ways to back up a computer that isn't fully functional. Ask if you need guidance.
If you installed the Java runtime distributed by Apple and still need it, you'll have to reinstall it. The same goes for Xcode.
*The linked support article refers to OS X 10.9 ("Mavericks"), but the procedure is the same for OS X 10.7 ("Lion") and later.

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