Mouse moves but won't open program

Recently moved my computer to another room. Plugged everything in and rebooted. All worked fine but requires frequent reboots because the mouse arrow will move but clicking will not open any program. On e rebooted it will work unti next time. What do I need to do?

Try doing a SMC and PRAM resets at least 2-3 each. For instructions please click Intel iMac SMC and PRAM resets. Post back with your results please.

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