Mouse moving but nothing else is responding. Had to PowerOff using button.

I have this persistent problem - After switching users, the iMac C2D 17" would not respond to any of the mouse click after the user desktop is displayed. The mouse pointer can be moved around, but won't respond to any clicks or any key clicks on the keyboard. I have 6 different users using the computer with their own accounts - big family with one iMac and an old Beige G3 . This seems to happen regardless of which account it is switching from/to. The only way to gain back the computer is by pressing the power button for some time or pulling the plug out of the outlet.
I have done basically everything I learnt from the forum and the web - Reset SMC, P-RAM, never sleep selected in Energy pref., cleanup permission, cache, etc (Applejack and/or Maintenence Automator). Anyone else experience the same or similar issues. Any help to resolve this is indeed appreciated.
Thanks.
KZ.
iMac C2D 17"   Mac OS X (10.4.8)  

Keyboard/Mouse are the original wired ones (wired white keyboard & wired mighty mouse). I do have 2 USB printers attached to it, usually are always switched on, an external Dell LCD monitor (connected via mini DVI adapter but switched off) and ipod firewire cable attached at the back (but no ipod connected). The internet Sharing (security with WEP/firewall open for only websharing, printer sharing and VOIP port UDP 5060) are also on to share connection with my Nokia E61.
Thanks again,
KZ

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