Mouse System Preferences not saved

I´m using a MacMini with the latest updtes and only apple harware, suddenly the mouse stoped puping up the dashboard, when I go to system preferences the scroll botton is not asigned to the dashboard, a click on it and then it works fine as long as i do not close system preferences, if I do close them then it stops working and if I reopen system preferences the button is again not asigned to the dashborad, the fact is that the preferences I define for the mouse regardless of the funcion i asign to them are not saved after closing system preferences.
Thanks for any help.
Mac Mini Mac OS X (10.4.8)

Sounds like you might have a series of corrupt preference (.plist) files, or else more problems.
likely a corrupt
com.apple.systempreferences.plist and a com.apple.dockpreferences.plist files in your User/Library folder
However it might not be just that alone
Run through this list of repairs in the order given (1-16)
Step by Step to fix your Mac
If you can't isolate the and solve problem by #16, then do #17 after backing up your data

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