Mouse/Trackpad won't work. What's step one?

Okay, this is irksome. The Wife's two month old iMac has just gotten a problem which renders it unusuable. The mouse and the trackpad work in the sense that the curser goes across the screen but I have no way of "clicking" anything. I have tried the trackpad, an wired Apple mouse and a cheapo wired generic mouse and I have used all different USB ports for the wired mice. Same thing. At this point, I pulled the plug and restarted it. Again, same thing.
I have Apple Care so I could call but I'd like to try to fix it myself before making the phone call. So any ideas?
Thanks.
Brian
(Haven't upgraded to Mountain Lion yet.)

Hi Brian, try this...
"Try Disk Utility
1. Insert the Mac OS X Install disc, then restart the computer while holding the C key.
2. When your computer finishes starting up from the disc, choose Disk Utility from the Installer menu at the top of the screen. (In Mac OS X 10.4 or later, you must select your language first.)
Important: Do not click Continue in the first screen of the Installer. If you do, you must restart from the disc again to access Disk Utility.
3. Click the First Aid tab.
4. Select your Mac OS X volume.
5. Click Repair. Disk Utility checks and repairs the disk."
http://docs.info.apple.com/article.html?artnum=106214
Then try a Safe Boot, (holding Shift key down at bootup), run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions, reboot when it completes.
(Safe boot may stay on the gray radian for a long time, let it go, it's trying to repair the Hard Drive.)

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