Mouse won't work after computer wakes

I have both the original iMac keyboard and mouse (wired) and also a (wired) Microsoft USB Keyboard and mouse set. It doesn't matter which set I'm using as this happens with both. Whenever the computer sleeps and is then required, the mouse won't function. It stays in the centre of the screen.
With the MS Kb and mouse combo I use an additional 4-port USB hub. I have the latest MS software (6.0 for Mac) installed for this set. When needed after awakening, the mouse just sits. No activity whatsoever. The only way to activate it is to unplug the USB connection from its port on the hub. Now it will work fine.
Using the Mac set, the Mac mouse is connected into the Mac keyboard USB port. There is no USB hub in this scenario. However, the same thing happens. I have to disconnect the mouse from the Mac keyboard and reconnect it.
Any idea what is happening here? When I first started the Mac or MS sets there was no problem. Could it be that one of the Mac software updates is causing a glitch?
The reason I use the MS keyboard and mouse (MS Natural Ergonomic Keyboard V1.0 and MS IntelliMouse Explorer 4.0) is because I prefer the keyboard layout. I have difficulty with the straight-across keyboards.
Looking forward to your responses. Thanks in advance.
Lynn
Intel Core Duo Mac OS X (10.4.7) 1 GB DDR2 SDRAM, Netgear Router

Here is a Knowledge Base article with things to consider;
Intel-based Mac: USB Keyboard or mouse stops responding
Also is the hub externally powered? Or does it draw power through the USB? Non-powered hubs have caused issues.

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