Moved library and now iTunes will not update

I moved my library to a thumb drive because it was getting too big for my harddrive.  This worked without fail until I filled up that drive, too.  I got a bigger one and moved everything there. This was about a month ago.  Everything was working fine until this morning when iTunes prompted me to update.  The update will not install because it is apparently trying to access the no longer extant E drive.  iTunes is now on F. 
I am running Windows 7 64 bit.
This is my first post to a forum and I am not terribly tech savvy so I apologize in advance for any misunderstandings.

Option 1 - The entire iTunes folder is on drive F:
Press and hold down shift as you launch iTunes, keep holding until asked to choose or create a library, click choose, browse to the iTunes and open the file iTunes Library.itl inside it.
Option 2 - Only the media folder is on F:
Press the WinLogoKey+R on your keyboard.
Type in Diskmgmt.msc and press enter.
Right-click on drive F: and select Change Drive Letter and Paths...
Click Change and change it to E: - if something is already using E change that first to G: or H: or...
iTunes should now work.
In either case, get another disk and start backing up.
tt2

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