MSI Z68a GD65 G3 Buzzing noise of hard drive over speakers

I finished building system
MSI Z68a GD65 G3
Fractal design define  r3 case
Core i7 2600k
2x MSI N460GTX 1Gd5 OC
16 gb DDR3 Ram
Corsair HX 850w PSU
CORSAIR GT3 90 gb ssd
Logitech Z5300 speaker set 5.1
+bunch of samsung 1 tb spinpoints
I noticed when i scrolled with my mouse wheel up or down, i hear a interfering noise low buzzing noise over the speakers 5.1 which are conected to on board sound card.
When i connect my headphone the sound still exists
It also occurs when i start up some applications and the hard drive is busy.
I tried enable/disable eup2013 and c1 and intel c1 etc... nothing works
With or without overclock it doesn matter.
Does anybody have a suggestion how to fix this problem? Thank you! Please help;-)

Sounds like a bad earth somewhere.
Is that a wired mouse ? Have you tried another mouse and keyboard ?
Can you test the board outside the case, on a non-conducting surface. No device used for the test to be mounted in the case.

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