Multiple apps & system prefs hanging constantly on Retina

Hi all,
I've started to have frequent problems on my Retina MBP. The machine is the 2.7 GHz model with 16 GB RAM and 512 GB SSD.
The problem is in almost all cases software freezing either upon launching them or trying to take the first action inside the application. To name some examples:
Chrome will often launch OK, then restore my tabs and hang. Will respond to nothing save for force quit.
System Preferences won't let me switch from the Desktop tab to the Screen Saver tab. When I click the latter it just hangs up. Force quit.
Adobe Premiere Pro will often stop displaying any video, especially if a change focus to another window/desktop. Will take commands and close cleanly, but it's rather useless without video, you know...
Excel 2011 will crash when I try to activate Solver. It will also crash randomly from time to time (no hang-ups so far).
These are 3rd party apps for sure, but the help I need is a little push in the right direction. Where to start debugging? All of these are legit, paid-for programs and I keep them up-to-date. Also, all of them have so far worked very well on this machine. Problems started appearing, I would say, about a week ago. At the moment, I cannot associate any particular updates with any of these with the start of the problems.
Needless to say it's pretty frustrating to have this happen on a supposedly one of the best laptops there is. Especially that I have had no problems with my previous Macs, or with any Apple products for that matter. Things that simply work was the one and only reason I switched over from PC's years ago.
I'd be really thankful for any help on this!
Best regards from cold, rainy Finland,
Joonas Häkkinen

Thanks, Clinton!
So here goes. I just started to experience a new kind of a problem. I have a DMG-file on my desktop that we use for moving images and project files around in our little business. I usually leave this file mounted most of the time without problems, including when I close the MBP's lid. I tend not to power it down, though lately have had to because of these problems.
So I opened the already mounted DMG-folder and noticed that none of the JPEGs inside have thumbnails anymore. Just those general icons of a blank paper. I cannot eject the DMG. If I try to mount it again, it seems like it's going OK and I get no errors, but nothing changes. I believe this was logged multiple times in relation to opening that folder:
6.10.12 7:59:01.124 PM Dock[186]: CGSSetWindowTransformAtPlacement: Failed
6.10.12 7:59:01.125 PM WindowServer[81]: _CGXSetWindowListMotionBlur: Invalid window 0xe5b
When I copied that bit and pasted it to this Chrome window the following appeared:
6.10.12 7:59:35.170 PM mdworker[2944]: Unable to talk to lsboxd
6.10.12 7:59:35.174 PM mdworker[2943]: Unable to talk to lsboxd
Also, I was copying another folder to my desktop, and now I notice it doesn't even have the folder icon but rather the same blank sheet icon. Upon double-clicking the folder will open but Finder will show no contents for it. However, I watched myself when it was copied and there were no errors. I get this when opening it:
6.10.12 8:01:17.638 PM quicklookd[2953]: [QL] _QLServerGetThumbnail: can't convert path to url
What do you make of this?

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