Must reinstall with every boot up

I'm using Thunderbird on a imac with OS 10.5. After I emptied the trash today I could not open TB. I went to the TB file in the Applications folder and it was empty. The icon remains on my desktop.
I downloaded the latest TB and reinstalled. That fixed it, or so I thought. When I reboot, TB no longer works and I have to reinstall again. Afterwards it works fine. None of my email files are lost.
Any suggestions would be appreciated.
Thanks,
Ken

how does one shut off the profoundly annoying yellow descriptor tags from showing up?
(these are the little pop-up tags when hovering the curser over and active button)
i have deselected 'toot tips' in several apps, but this obviously is an OS script running in the
background.
help?
hans

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    In the Security & Privacy pane of System Preferences, select the General tab. The radio button marked Anywhere  should not be selected. If it is, click the lock icon to unlock the settings, then select one of the other buttons. After that, don't ignore a warning that you are about to run or install an application from an unknown developer.
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