My copy of Adobe InDesign cs4 will not open a regular idml file.

I opened my document, and all it said was "cannot open the file "Tightsketch_charrette2.idml". Adobe InDesign may not support the file format, a plug-in that supports the file format may be missing, or the file may be open in another application" I tried opening other idmls that I knew were not corrupted and I recieved the same message. I checked the plugins, they are all enabled.  I quit all other programs, no luck.  I restarted the macbook, no luck again.  Could I recieve some help?  My Indesign cs4 is fully updated and Im having all these problems.

I have good news, and bad news.
The good news is that the file opens correctly here in both CS5.5 and CS4. The bad news is that means there's a problem with your CS4.
I would start out by trashing your preferences. It's fast, easy to do, and not overly destructive, and if you are lucky it will even solve the problem, but I wouldn't put the odds of success at more than 50/50. See Replace Your Preferences
Do you have a Time Machine backup? If you do, the next thing I would try is restoring the InDesign application folder from a time before the problem started.
If all else fails, it's probably time to bite the bullet and break out the installer. First try running a "repair" install on top of what's there. If that, too, fails, then I would uninstall CS4, run the CS5 clean tool (which can also clean up CS4 -- see Resolve installation problems with CS5 Cleaner Tool), then restart the computer and reinstall. If you have any customized stuff you should make copies of things like shorcut sets and workspaces that you can put back as explained in the thread on resetting the prefs.

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