My f5 and f6 keys won't work on a game i play?

I play a game called runescape and there is hotkeys which are f1-f5 mainly and i am trying to use these hotkeys to do certian things faster and my F5-F6 won't work, please help i'm a new mac user since last christmas!

You should read this answer posted by another member  and try
https://discussions.apple.com/message/10793204#10793204
if that fails
Try a PRAM Reset
http://support.apple.com/kb/ht1379
SMC Reset
http://support.apple.com/kb/HT3964
then use poster fane_J sugestion

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