My I mac 27 late 2009 will not start up I get to the grey screen with the mouse cursor but it stays that way. if I press shift during the boot i works into safe mode. any idea?

It gets to the grey screen and the mouse point sometime show up but noting more.
when I press shift it does load up into safe mode
i re-installed lion no changes

Restart you Mac holding the "Control + R " keys then run the Restore feature.

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