My I Mac is very slow or not responding.  Mail takes forever to open and pinwheel continues for along time

My I Mac, using 10.8.4 is very slow, mail takes forever to open and the spinning pinwheel starts every time I try to use mail.  any suggestions?

What year, screen size, CPU speed and amount of RAM installed?
How full is your Mac's hard drive?
How full is your Apple Mail?
How many applications do you run simultaneously in the background while working in another application?
Do you run any antivirus software on your Mac? Antivirus software can slow down the normal operation of OS X.
Do you run any "crapware" like Mackeeper or any other type of "crapware" like so called hard drive "cleaning" apps?

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