My iMac has trouble loading fonts (and speakers) on startup.

Some mornings my brand new work iMac (running 10.7.2) has trouble loading fonts on startup. Sometimes the speakers don't appear to be connected/active either. Both problems go away for the day once I've restarted the computer once or twice. Any ideas on why this is?

Ok, ready?
1.  How many fonts do you have?
2.  How did you install them?
3.  Which version of InDesign?
4.  Your speakers:  If external, is there a Lion update for them?
5.  Have you checked your preferences for "Sound?

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