My itunes won't update from 10.0 to 10.5.

My iTunes won't update from 10.0 to 10.5.  Every time I try it says that the itunes64 folder is missing.  I have tried to download it manually and repair the connection to the folder but it still won't download.  Please help.

Every time I try it says that the itunes64 folder is missing.
Doublechecking. Is it saying that the itunes64.msi can't be found?

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