My iWeb can't open. A sign comes up and says:"Can't open file "~/Library/Application Support/iWeb/Domain.sites2." Help?

I love iWeb. It has many advantages over on-line web-builders, but finding help is not easy.
My iWeb just stopped working. When I try to open it, a sign comes up "Can’t open file “~/Library/Application Support/iWeb/Domain.sites2.”
Can anyone help we fix this error and get back to work?
David aT [email protected]

Happens a lot :
Can't open file...
Solution is nill other than delete the prefs.

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