My Left-click on mouse is not working on mac os 10.8.2 mac mini. Please help ?

Thank you for reading and helping out !
All of a sudden, my left click on microsoft optical mouse stopped working. Then it worked for sometime then permanently stopped working after an hour. (its been 24 hours now). It was working fine before.
Here is what I have tried so far.
Tried Replacement optical mouse, which was not detected. so can't even use a replacement mouse.. it only seems to recognize original mouse and respond to it only.
I have turned Bluetooth off so that shouldn't be a cause.
unplugged keyboard and still left click on mouse not working.
unplugged computer and all cables for more than 6 hours.. still not working...
couldn't zap pram (for some reason being a microsoft keyboard ?? would you have proper instructions on how to to do this in windows keyboard??? )
My Specs: mac mini 10.8.2 with microsoft ergnomic keyboard and basic microsoft optical mouse.
i appreciate any help you would provide to get this solved!
Thank you.

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