My left mouse click randomly quits on both my iMac mouse and my wacom tablet.  How can I fix this?

Throughout the day the left mouse click quits.  I can right click with my mouse but not left click.  It happens on my wacom mouse, the pen mouse AND my iMac mouse that was bought with the computer.  Restarting or completely shutting down the computer does not get it to reboot. It will come back randomly too.  It's so odd and I do not have an explination why this is happening. 
I've looked for software updates but can not find any on the apple site OR wacom site.
Please help?

Please read this whole message before doing anything.
This procedure is a diagnostic test. It’s unlikely to solve your problem. Don’t be disappointed when you find that nothing has changed after you complete it.
The purpose of this exercise is to determine whether the problem is caused by third-party system modifications that load automatically at startup or login. Disconnect all wired peripherals except those needed for the test, and remove all aftermarket expansion cards. Boot in safe mode and log in to the account with the problem. The instructions provided by Apple are as follows:
Be sure your Mac is shut down.
Press the power button.
Immediately after you hear the startup tone, hold the Shift key. The Shift key should be held as soon as possible after the startup tone, but not before the tone.
Release the Shift key when you see the gray Apple icon and the progress indicator (looks like a spinning gear).
Safe mode is much slower to boot and run than normal, and some things won’t work at all, including wireless networking on certain Macs.
The login screen appears even if you usually log in automatically. You must know your login password in order to log in. If you’ve forgotten the password, you will need to reset it before you begin.
Test while in safe mode. Same problem(s)?
After testing, reboot as usual (i.e., not in safe mode.)

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