My mac is getting slower and slower - here is the Etrecheck information on my mac.

Are there any issues that need to be addressed for my Mac?
Thank you for your help.  Tis is my first Mac and I just want it to run smoothly,  I'm also having difficulty trying to set up my Time machine.
EtreCheck version: 1.9.12 (48)
Report generated June 24, 2014 at 9:31:48 AM EDT
Hardware Information:
  iMac (27-inch, Mid 2010) (Verified)
  iMac - model: iMac11,3
  1 3.2 GHz Intel Core i3 CPU: 2 cores
  4 GB RAM
Video Information:
  ATI Radeon HD 5670 - VRAM: 512 MB
  iMac 2560 x 1440
System Software:
  OS X 10.9.3 (13D65) - Uptime: 0 days 0:17:24
Disk Information:
  ST31000528AS disk0 : (1 TB)
  EFI (disk0s1) <not mounted>: 209.7 MB
  Macintosh HD (disk0s2) / [Startup]: 999.35 GB (803.31 GB free)
  Recovery HD (disk0s3) <not mounted>: 650 MB
  OPTIARC DVD RW AD-5680H
USB Information:
  EPSON USB2.0 MFP(Hi-Speed)
  Apple Internal Memory Card Reader
  Apple Inc. BRCM2046 Hub
  Apple Inc. Bluetooth USB Host Controller
          USB Flash Memory 4.01 GB
  ZETA HD-2 (disk1s1) /Volumes/ZETA HD-2: 4 GB (3.96 GB free)
  Logitech Logitech USB Headset
  Apple Computer, Inc. IR Receiver
  Apple Inc. Built-in iSight
Gatekeeper:
  Anywhere
Launch Daemons:
  [loaded] com.adobe.fpsaud.plist Support
  [loaded] com.dervishsoftware.MailHubInstallerHelper.plist Support
  [running] com.iobit.AMCDaemon.plist Support
  [loaded] com.microsoft.office.licensing.helper.plist Support
  [invalid] com.oracle.java.Helper-Tool.plist
Launch Agents:
  [invalid] com.oracle.java.Java-Updater.plist
  [running] net.culater.SIMBL.Agent.plist Support
User Launch Agents:
  [loaded] com.adobe.ARM.[...].plist Support
  [failed] com.dervishsoftware.MailHubUserAgent.plist Support
  [loaded] com.google.keystone.agent.plist Support
  [running] com.spotify.webhelper.plist Support
User Login Items:
  iTunesHelper
  Garmin Express Service
  Dropbox
  Degrees
  Calendar
  Mail
  1Password
  SpeechSynthesisServer
Internet Plug-ins:
  Google Earth Web Plug-in: Version: 7.0 Support
  Default Browser: Version: 537 - SDK 10.9
  AdobePDFViewerNPAPI: Version: 11.0.07 - SDK 10.6 Support
  FlashPlayer-10.6: Version: 14.0.0.125 - SDK 10.6 Support
  Silverlight: Version: 5.1.20913.0 - SDK 10.6 Support
  Flash Player: Version: 14.0.0.125 - SDK 10.6 Support
  QuickTime Plugin: Version: 7.7.3
  iPhotoPhotocast: Version: 7.0 - SDK 10.8
  NP_2020Player_IKEA: Version: 5.0.94.1 - SDK 10.6 Support
  AdobePDFViewer: Version: 11.0.07 - SDK 10.6 Support
  CouponPrinter-FireFox_v2: Version: 1.1.10 - SDK 10.6 Support
  GarminGpsControl: Version: 4.0.4.0 Release - SDK 10.6 Support
  SharePointBrowserPlugin: Version: 14.0.0 Support
  DirectorShockwave: Version: 12.0.2r122 - SDK 10.6 Support
Safari Extensions:
  Evernote Web Clipper: Version: 5.9.15
  Translate: Version: 1.0.6
  iTube Studio: Version: 4.3.0.0
  AdBlock: Version: 2.6.4
  Ultimate Status Bar: Version: 1.3
  Add To Amazon Wish List: Version: 1.8
  AdBlock: Version: 2.6.0
  Cookie Stumbler: Version: 1.0.3
  SafariRestore: Version: 5.6.2
  Reload Button: Version: 1.2
  AdBlock: Version: 2.7.3
  1Password: Version: 3.9.19
  Facebook Improved: Version: 1.8
  Translate: Version: 1.0.6
  Like.fm for Safari: Version: 1.0.9
  Facebook Cleaner: Version: 3.3
  Translate: Version: 1.1
  ClickToFlash: Version: 2.9.4
  1Password: Version: 4.0.1
  Reload Button: Version: 1.2
  iMedia Converter Deluxe  : Version: 3.1.0
Audio Plug-ins:
  BluetoothAudioPlugIn: Version: 1.0 - SDK 10.9
  AirPlay: Version: 2.0 - SDK 10.9
  AppleAVBAudio: Version: 203.2 - SDK 10.9
  iSightAudio: Version: 7.7.3 - SDK 10.9
iTunes Plug-ins:
  Quartz Composer Visualizer: Version: 1.4 - SDK 10.9
3rd Party Preference Panes:
  Flash Player  Support
  MagicPrefs  Support
Time Machine:
  Time Machine not configured!
Top Processes by CPU:
      4% mds
      2% WindowServer
      2% mds_stores
      0% fontd
      0% AdobeReader
Top Processes by Memory:
  434 MB com.apple.MediaLibraryService
  229 MB Safari
  229 MB com.apple.IconServicesAgent
  180 MB Finder
  156 MB iTunes
Virtual Memory Information:
  65 MB Free RAM
  1.66 GB Active RAM
  1.61 GB Inactive RAM
  624 MB Wired RAM
  507 MB Page-ins
  6 MB Page-outs

Please describe the problem in as much relevant detail as possible. The "etrecheck" fad hasn't made that step any less necessary. The better your description, the better the chance of a solution.
For example, if the computer is slow, which specific actions are slow? Is it slow all the time, or only sometimes? When did it start to be slow? Did you change anything just before it started? Have you seen any alerts or error messages? Have you done anything to try to fix it? Most importantly, do you have a current backup of all data? If the answer to the last question is "no," back up now. Ask if you need guidance. Do nothing else until you have a backup.

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    Darwin Kernel Version 12.0.0: Sun Jun 24 23:00:16 PDT 2012; root:xnu-2050.7.9~1/RELEASE_X86_64
    Kernel UUID: 8D5F8EF3-9D12-384B-8070-EF2A49C45D24
    Kernel slide:     0x0000000000a00000
    Kernel text base: 0xffffff8000c00000
    System model name: MacBookPro8,1 (Mac-94245B3640C91C81)
    System uptime in nanoseconds: 34746882047
    last loaded kext at 34653635932: com.apple.driver.AppleUpstreamUserClient          3.5.10 (addr 0xffffff7f8213d000, size 36864)
    loaded kexts:
    com.apple.driver.AppleUpstreamUserClient          3.5.10
    com.apple.iokit.IOUserEthernet          1.0.0d1
    com.apple.driver.AppleIntelHD3000Graphics          8.0.0
    com.apple.iokit.IOBluetoothSerialManager          4.0.9f8
    com.apple.iokit.IOBluetoothUSBDFU          4.0.9f8
    com.apple.iokit.BroadcomBluetoothHCIControllerUSBTransport          4.0.9f8
    com.apple.driver.SMCMotionSensor          3.0.2d6
    com.apple.driver.AppleSMCPDRC          1.0.0
    com.apple.driver.AppleSMCLMU          2.0.2d0
    com.apple.Dont_Steal_Mac_OS_X          7.0.0
    com.apple.driver.ApplePolicyControl          3.2.6
    com.apple.driver.ACPI_SMC_PlatformPlugin          1.0.0
    com.apple.driver.AppleLPC          1.6.0
    com.apple.driver.AppleIntelPenrynProfile          17
    com.apple.driver.AppleIntelNehalemProfile          11
    com.apple.driver.AppleIntelMeromProfile          19
    com.apple.driver.AppleIntelSNBGraphicsFB          8.0.0
    com.apple.driver.AppleMuxControl          3.2.6
    com.apple.driver.AppleBacklight          170.2.3
    com.apple.driver.AppleMCCSControl          1.0.33
    com.apple.driver.AppleUSBTCButtons          235.4
    com.apple.driver.AppleUSBTCKeyEventDriver          235.4
    com.apple.driver.AppleUSBTCKeyboard          235.4
    com.apple.driver.AppleIRController          320.15
    com.apple.iokit.SCSITaskUserClient          3.5.1
    com.apple.driver.AppleFileSystemDriver          3.0.1
    com.apple.AppleFSCompression.AppleFSCompressionTypeDataless          1.0.0d1
    com.apple.AppleFSCompression.AppleFSCompressionTypeZlib          1.0.0d1
    com.apple.BootCache          34
    com.apple.driver.XsanFilter          404
    com.apple.iokit.IOAHCIBlockStorage          2.2.0
    com.apple.driver.AppleUSBHub          5.1.6
    com.apple.iokit.AppleBCM5701Ethernet          3.2.5b3
    com.apple.driver.AirPort.Brcm4331          600.15.20
    com.apple.driver.AppleAHCIPort          2.4.0
    com.apple.driver.AppleSDXC          1.2.2
    com.apple.driver.AppleUSBEHCI          5.1.5
    com.apple.driver.AppleFWOHCI          4.9.5
    com.apple.driver.AppleUSBUHCI          5.1.5
    com.apple.driver.AppleEFINVRAM          1.6.1
    com.apple.driver.AppleSmartBatteryManager          161.0.0
    com.apple.driver.AppleRTC          1.5
    com.apple.driver.AppleACPIButtons          1.6
    com.apple.driver.AppleHPET          1.7
    com.apple.driver.AppleSMBIOS          1.9
    com.apple.driver.AppleACPIEC          1.6
    com.apple.driver.AppleAPIC          1.6
    com.apple.driver.AppleIntelCPUPowerManagementClient          196.0.0
    com.apple.nke.applicationfirewall          4.0.39
    com.apple.security.quarantine          2
    com.apple.driver.AppleIntelCPUPowerManagement          196.0.0
    com.apple.iokit.IOSurface          86.0.2
    com.apple.iokit.IOSerialFamily          10.0.6
    com.apple.driver.AppleSMBusPCI          1.0.10d0
    com.apple.iokit.AppleBluetoothHCIControllerUSBTransport          4.0.9f8
    com.apple.iokit.IOFireWireIP          2.2.5
    com.apple.driver.AppleHDAController          2.3.0f2
    com.apple.iokit.IOHDAFamily          2.3.0f2
    com.apple.iokit.IOBluetoothFamily          4.0.9f8
    com.apple.driver.AppleSMC          3.1.3d11
    com.apple.driver.IOPlatformPluginLegacy          1.0.0
    com.apple.driver.IOPlatformPluginFamily          5.2.0d16
    com.apple.driver.AppleThunderboltEDMSink          1.1.8
    com.apple.driver.AppleThunderboltEDMSource          1.1.8
    com.apple.driver.AppleThunderboltDPOutAdapter          1.8.5
    com.apple.iokit.AppleProfileFamily          40
    com.apple.driver.AppleGraphicsControl          3.2.6
    com.apple.driver.AppleBacklightExpert          1.0.4
    com.apple.iokit.IONDRVSupport          2.3.4
    com.apple.driver.AppleSMBusController          1.0.10d0
    com.apple.iokit.IOGraphicsFamily          2.3.4
    com.apple.driver.AppleThunderboltDPInAdapter          1.8.5
    com.apple.driver.AppleThunderboltDPAdapterFamily          1.8.5
    com.apple.driver.AppleThunderboltPCIDownAdapter          1.2.5
    com.apple.driver.AppleUSBMultitouch          235.7
    com.apple.iokit.IOUSBHIDDriver          5.0.0
    com.apple.driver.AppleUSBMergeNub          5.1.5
    com.apple.driver.AppleUSBComposite          5.0.0
    com.apple.iokit.IOSCSIMultimediaCommandsDevice          3.5.1
    com.apple.iokit.IOBDStorageFamily          1.7
    com.apple.iokit.IODVDStorageFamily          1.7.1
    com.apple.iokit.IOCDStorageFamily          1.7.1
    com.apple.iokit.IOAHCISerialATAPI          2.5.0
    com.apple.iokit.IOSCSIArchitectureModelFamily          3.5.1
    com.apple.iokit.IOUSBUserClient          5.0.0
    com.apple.iokit.IOEthernetAVBController          1.0.2b1
    com.apple.iokit.IO80211Family          500.15
    com.apple.iokit.IONetworkingFamily          3.0
    com.apple.iokit.IOAHCIFamily          2.2.0
    com.apple.driver.AppleThunderboltNHI          1.6.0
    com.apple.iokit.IOThunderboltFamily          2.0.3
    com.apple.iokit.IOFireWireFamily          4.5.5
    com.apple.iokit.IOUSBFamily          5.1.6
    com.apple.driver.AppleEFIRuntime          1.6.1
    com.apple.iokit.IOHIDFamily          1.8.0
    com.apple.iokit.IOSMBusFamily          1.1
    com.apple.security.sandbox          220
    com.apple.kext.AppleMatch          1.0.0d1
    com.apple.security.TMSafetyNet          7
    com.apple.driver.DiskImages          344
    com.apple.iokit.IOStorageFamily          1.8
    com.apple.driver.AppleKeyStore          28.18
    com.apple.driver.AppleACPIPlatform          1.6
    com.apple.iokit.IOPCIFamily          2.7
    com.apple.iokit.IOACPIFamily          1.4
    com.apple.kec.corecrypto          1.0
    Model: MacBookPro8,1, BootROM MBP81.0047.B27, 2 processors, Intel Core i7, 2.8 GHz, 4 GB, SMC 1.68f98
    Graphics: Intel HD Graphics 3000, Intel HD Graphics 3000, Built-In, 384 MB
    Memory Module: BANK 0/DIMM0, 2 GB, DDR3, 1333 MHz, 0x80AD, 0x484D54333235533642465238432D48392020
    Memory Module: BANK 1/DIMM0, 2 GB, DDR3, 1333 MHz, 0x80AD, 0x484D54333235533642465238432D48392020
    AirPort: spairport_wireless_card_type_airport_extreme (0x14E4, 0xD6), Broadcom BCM43xx 1.0 (5.106.98.81.20)
    Bluetooth: Version 4.0.9f8 10405, 2 service, 18 devices, 0 incoming serial ports
    Network Service: Ethernet, Ethernet, en0
    Network Service: FireWire, FireWire, fw0
    Network Service: Wi-Fi, AirPort, en1
    Serial ATA Device: TOSHIBA MK7559GSXF, 750.16 GB
    Serial ATA Device: MATSHITADVD-R   UJ-8A8
    USB Device: FaceTime HD Camera (Built-in), apple_vendor_id, 0x8509, 0xfa200000 / 3
    USB Device: hub_device, 0x0424  (SMSC), 0x2513, 0xfa100000 / 2
    USB Device: Apple Internal Keyboard / Trackpad, apple_vendor_id, 0x0253, 0xfa120000 / 5
    USB Device: BRCM2070 Hub, 0x0a5c  (Broadcom Corp.), 0x4500, 0xfa110000 / 4
    USB Device: Bluetooth USB Host Controller, apple_vendor_id, 0x821a, 0xfa113000 / 8
    USB Device: hub_device, 0x0424  (SMSC), 0x2513, 0xfd100000 / 2
    USB Device: IR Receiver, apple_vendor_id, 0x8242, 0xfd110000 / 3
    I hope someone can help.
    Thank you.

    Boot using safe mode.
    Delete this file:
    /System/Library/Extensions/AppleProfileFamily.kext

  • Shut down and boot are slow, here are the console messages

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    *11/13/07 2:17:57 PM com.apple.launchd[1] (org.cups.cupsd) Unknown key: SHAuthorizationRight*
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    11/13/07 2:18:32 PM com.apple.launchd[1] (com.apple.UserEventAgent-LoginWindow[85]) Exited: Terminated
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