My mac pro is taking a long time to open files

When I rey and open applications like Finder, it is taking a long time to open or it hangs how can I fix this
I have OS10.7.2 and 300GB left out of 500GB.
Mac book peo 17
Message was edited by: waldoamt

How large is your hard drive and how much hard drive space do you have left?
Which Macbook Pro do you have?
Which os & version are you using?

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