My Mac using os 105.8 has a unresponsive Mail problem. Can anyone help?

I'm unable top use the Mail. It starts up - downloads E-mails and then become s unresponsive (the system just displays the 'sp;inning disk' symbol and I have to force it to quit. The system has sent multiple "system quit while responsive" reports to Apple. What can I do? The problem developed overnight (with no warning problems) several weeks ago. Can anyone help please?

Quit, uninstall or disable all third party software, plug-ins etc especially virus protection
Verify your disk with Disk Utility
Repair permissions with Disk Utility
Restart your Mac
Post the next crash report here

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