My mac will not allow me to run my itunes software update?

My macbook air will not allow me to run my software update for itunes. It will go through the entire process until the last step and then say that it is not supported. Any help or advice???

Try disabling Protected Mode [Edit | Preferences | Security (Enhanced)].
Note that Reader XI is not officially supported on Vista; Reader X (10.1.10) is the latest Reader version for Vista.

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