My MacBook has question marks on all folders and won't run ANY program. Help!

A week ago I was editing some photographs in Photoshop CS 5 extended. My computer has been running slow for a while so I thought that I would finish these files and then clear it of some photos since I know I've recently uploaded several gbs onto it.
The next day it was frozen. I had to shut it down and restart. It came on and now every folder has a question mark on it and none of the programs will open. They just bounce up and down and then the menu bar says Application not responding.
I have no idea what I need to do. I was going to update to Lion but I'm unsure if that's what I should do or if it needs some TLC from the apple store.
Help?

A professional will image your drive and attempt a bit by bit file recovery method directly from the drive itself.
You see when you delete something, it's not quite erased yet, but the space the file took is available to be overwritten, so it's only a matter of time before that occurs and the file is really gone.
So they will recover what they can, and then restore your machine and it's software and return the recovered files.
The TimeMachine is certainly going to assist, good thing you got it.
The trick is to hire someone and quit using the computer until they rescue you, show you in person how to rescue yourself .
Good Luck

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