My macbook is running extremely slow...

Question

Here is my Entresoft report:
Hardware Information:
          MacBook Pro (13-inch, Early 2011)
          MacBook Pro - model: MacBookPro8,1
          1 2.3 GHz Intel Core i5 CPU: 2 cores
          4 GB RAM
Video Information:
          Intel HD Graphics 3000 - VRAM: 384 MB
System Software:
          OS X 10.9.1 (13B42) - Uptime: 0 days 21:3:30
Disk Information:
          Hitachi HTS545032B9A302 disk0 : (320.07 GB)
                    EFI (disk0s1) <not mounted>: 209.7 MB
                    Macintosh HD (disk0s2) /: 319.21 GB (88.49 GB free)
                    Recovery HD (disk0s3) <not mounted>: 650 MB
          OPTIARC DVD RW AD-5970H 
USB Information:
          Apple Computer, Inc. IR Receiver
          Apple Inc. FaceTime HD Camera (Built-in)
          Toshiba External USB 3.0 1.5 TB
                    EFI (disk1s1) <not mounted>: 209.7 MB
                    External Drive (disk1s2) /Volumes/External Drive: 1.5 TB (1.25 TB free)
          Apple Inc. BRCM2070 Hub
                    Apple Inc. Bluetooth USB Host Controller
          Apple Inc. Apple Internal Keyboard / Trackpad
FireWire Information:
Thunderbolt Information:
          Apple Inc. thunderbolt_bus
Kernel Extensions:
          com.McAfee.kext.AppProtection          (1.1.0d1)
          com.mcafee.kext.Virex          (1.1.0d1)
Problem System Launch Daemons:
Problem System Launch Agents:
Launch Daemons:
          [loaded] com.adobe.fpsaud.plist 3rd-Party support link
          [loaded] com.flipvideo.FlipShareServer.launchd.plist 3rd-Party support link
          [invalid] com.mcafee.ssm.ScanManager.plist
          [loaded] com.mcafee.virusscan.fmpd.plist 3rd-Party support link
          [loaded] com.microsoft.office.licensing.helper.plist 3rd-Party support link
          [loaded] org.sane-project.saned.plist 3rd-Party support link
Launch Agents:
          [loaded] com.divx.dms.agent.plist 3rd-Party support link
          [loaded] com.divx.update.agent.plist 3rd-Party support link
          [loaded] com.flipvideo.FlipShare.AutoRun.plist 3rd-Party support link
          [loaded] com.hp.messagecenter.launcher.plist 3rd-Party support link
          [loaded] com.hp.productresearch.plist 3rd-Party support link
          [loaded] com.lexmark.bmspecificlaunchd.plist 3rd-Party support link
          [loaded] com.mcafee.menulet.plist 3rd-Party support link
          [loaded] com.mcafee.reporter.plist 3rd-Party support link
User Launch Agents:
          [loaded] com.adobe.ARM.[...].plist 3rd-Party support link
          [loaded] com.divx.agent.postinstall.plist 3rd-Party support link
          [loaded] com.google.keystone.agent.plist 3rd-Party support link
User Login Items:
          GrowlHelperApp
          Calendar
          AdobeResourceSynchronizer
Internet Plug-ins:
          OVSHelper: Version: 1.1 3rd-Party support link
          Default Browser: Version: 537 - SDK 10.9
          Flip4Mac WMV Plugin: Version: 2.3.8.1 3rd-Party support link
          DivX Plus Web Player: Version: 2.3 - SDK 10.5 3rd-Party support link
          RealPlayer Plugin: Version: Unknown
          AdobePDFViewerNPAPI: Version: 11.0.04 - SDK 10.6 3rd-Party support link
          FlashPlayer-10.6: Version: 11.9.900.170 - SDK 10.6 3rd-Party support link
          Silverlight: Version: 5.1.20125.0 - SDK 10.6 3rd-Party support link
          Flash Player: Version: 11.9.900.170 - SDK 10.6 3rd-Party support link
          QuickTime Plugin: Version: 7.7.3
          iPhotoPhotocast: Version: 7.0 - SDK 10.8
          SharePointBrowserPlugin: Version: 14.3.9 - SDK 10.6 3rd-Party support link
          AdobePDFViewer: Version: 11.0.04 - SDK 10.6 3rd-Party support link
          SiteAdvisor: Version: 2.0 - SDK 10.5 3rd-Party support link
          RL Secure Plug-In Layer: Version: (null) - SDK 10.5 3rd-Party support link
Audio Plug-ins:
          BluetoothAudioPlugIn: Version: 1.0 - SDK 10.9
          AirPlay: Version: 1.9 - SDK 10.9
          AppleAVBAudio: Version: 2.0.0 - SDK 10.9
          iSightAudio: Version: 7.7.3 - SDK 10.9
User Internet Plug-ins:
          ContentManager: Version: (null) - SDK 10.5 3rd-Party support link
          RocketEngine: Version: (null) - SDK 10.5 3rd-Party support link
          UploadManager: Version: (null) - SDK 10.5 3rd-Party support link
3rd Party Preference Panes:
          Flash Player  3rd-Party support link
          Flip4Mac WMV  3rd-Party support link
          Growl  3rd-Party support link
          SANE  3rd-Party support link
          Tuxera NTFS  3rd-Party support link
Bad Fonts:
          None
Old Applications:
          /Library/Application Support/Microsoft/MERP2.0
                    Microsoft Error Reporting:          Version: 2.2.9 - SDK 10.4 3rd-Party support link
                    Microsoft Ship Asserts:          Version: 1.1.4 - SDK 10.4 3rd-Party support link
          SiteAdvisor:          Version: 2.0 - SDK 10.5 3rd-Party support link
                    /Applications/SiteAdvisor/SiteAdvisor.app
          /Library/Application Support/DivX
                    DivXMediaServer:          Version: 1.2 - SDK 10.5 3rd-Party support link
                    DivXTransferWizard:          Version: 1.0.5 (Build 1.1.0.10) - SDK 10.5 3rd-Party support link
                    DMSLaunch:          Version: 1.0 - SDK 10.5 3rd-Party support link
          SLLauncher:          Version: 1.0 - SDK 10.5 3rd-Party support link
                    /Library/Application Support/Microsoft/Silverlight/OutOfBrowser/SLLauncher.app
          /Applications/Microsoft Office 2011/Office
                    Microsoft Graph:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Database Utility:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Office Reminders:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Upload Center:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    My Day:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    SyncServicesAgent:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Open XML for Excel:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Alerts Daemon:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Database Daemon:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Chart Converter:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Clip Gallery:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
          /Applications/Microsoft Office 2011
                    Microsoft PowerPoint:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Excel:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Outlook:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Word:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    Microsoft Document Connection:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
          Microsoft Language Register:          Version: 14.3.9 - SDK 10.5 3rd-Party support link
                    /Applications/Microsoft Office 2011/Additional Tools/Microsoft Language Register/Microsoft Language Register.app
          Solver:          Version: 1.0 - SDK 10.5 3rd-Party support link
                    /Applications/Microsoft Office 2011/Office/Add-Ins/Solver.app
          Microsoft AutoUpdate:          Version: 2.3.6 - SDK 10.4 3rd-Party support link
                    /Library/Application Support/Microsoft/MAU2.0/Microsoft AutoUpdate.app
          HP Photo Creations:          Version: 1.0.0.12412 - SDK 10.5 3rd-Party support link
          DivX Converter:          Version: 9.1.2 (Build 9.2.0.16) - SDK 10.5 3rd-Party support link
          DivX Player:          Version: 9.1.2 (Build 11.0.1.52) - SDK 10.5 3rd-Party support link
Time Machine:
          Mobile backups: ON
          Auto backup: YES
          Volumes being backed up:
                    Macintosh HD: Disk size: 297.29 GB Disk used: 214.88 GB
          Destinations:
                    External Drive [Local] (Last used)
                    Total size: 1 
                    Total number of backups: 29
                    Oldest backup: 2013-07-14 23:33:51 +0000
                    Last backup: 2014-01-02 17:43:10 +0000
                    Size of backup disk: Excellent
                              Backup size 1  > (Disk size 297.29 GB X 3)
          Time Machine details may not be accurate.
          All volumes being backed up may not be listed.
          /sbin excluded from backup!
          /usr excluded from backup!
          /System excluded from backup!
          /bin excluded from backup!
          /private excluded from backup!
          /Library excluded from backup!
          /Applications excluded from backup!
Top Processes by CPU:
               5%          appProtd
               3%          WindowServer
               2%          VShieldScanManager
               1%          EtreCheck
               1%          HP Device Monitor
Top Processes by Memory:
          160 MB          mds_stores
          119 MB          Finder
          106 MB          Safari
          90 MB          Mail
          90 MB          Microsoft Excel
Virtual Memory Information:
          83 MB          Free RAM
          1.39 GB          Active RAM
          1.32 GB          Inactive RAM
          968 MB          Wired RAM
          1.81 GB          Page-ins
          155 MB          Page-outs

Answer 1

If you don't already have a current backup, back up all data before doing anything else. This procedure is a diagnostic  test. It changes nothing, for better or worse, and therefore will not, in itself, solve your problem. The backup is necessary on general principle, not because of anything suggested in this comment. There are ways to back up a computer that isn't fully functional. Ask if you need guidance.
Third-party system modifications are a common cause of usability problems. By a “system modification,” I mean software that affects the operation of other software — potentially for the worse. The procedure will help identify which such modifications you've installed, as well as some other aspects of the configuration that may be related to the problem.
Don’t be alarmed by the seeming complexity of these instructions — they’re easy to carry out. Here's a brief summary: In each of two steps, you copy a line of text from this web page into a window in another application. You wait about a minute. Then you paste some other text, which will have been copied automatically, back into a reply on this page. The sequence is copy; paste; paste again. That's all there is to it. Details follow.
You may have started the computer in "safe" mode. Preferably, these steps should be taken while booted in “normal” mode. If the system is now running in safe mode and is bootable in normal mode, reboot as usual. If it only boots in safe mode, use that.
Below are instructions to enter UNIX shell commands. They do nothing but produce human-readable output. However, you need to think carefully before running any program at the behest of a stranger on a public message board. If you question the safety of the procedure suggested here — which you should — search this site for other discussions in which it’s been followed without any report of ill effects. If you can't satisfy yourself that these instructions are safe, don't follow them.
The commands will line-wrap or scroll in your browser, but each one is really just a single long line, all of which must be selected. You can accomplish this easily by triple-clicking anywhere in the line. The whole line will highlight, and you can then copy it.
If you have more than one user account, Step 2 must be taken as an administrator. Ordinarily that would be the user created automatically when you booted the system for the first time. Step 1 should be taken as the user who has the problem, if different. Most personal Macs have only one user, and in that case this paragraph doesn’t apply.
Launch the Terminal application in any of the following ways: 
☞ Enter the first few letters of its name into a Spotlight search. Select it in the results (it should be at the top.) 
☞ In the Finder, select Go ▹ Utilities from the menu bar, or press the key combination shift-command-U. The application is in the folder that opens. 
☞ Open LaunchPad. Click Utilities, then Terminal in the icon grid. 
When you launch Terminal, a text window will open with a line already in it, ending either in a dollar sign (“$”) or a percent sign (“%”). If you get the percent sign, enter “sh” and press return. You should then get a new line ending in a dollar sign. 
Step 1 
Triple-click anywhere in the line of text below on this page to select it:
PB=/usr/libexec/PlistBuddy; PR () { [[ "$o" ]] && o=$(sed 's/^/   /' <<< "$o") && printf '\n%s:\n\n%s\n' "$1" "$o"; }; PC () { o=$(grep [^[:blank:]] "$2"); PR "$1"; }; PF () { o=$($PB -c Print "$2" | awk -F'= ' \/$3'/{print $2}'); PR "$1"; }; PN () { [[ $o -eq 0 ]] || printf "\n%s: %s\n" "$1" $o; }; { system_profiler SPSoftwareDataType | sed '8!d;s/^ *//'; o=$(system_profiler SPDiagnosticsDataType | sed '5,6!d'); fgrep -q P <<< "$o" && o=; PR "POST"; o=$(($(vm_stat | awk '/Pageo/{sub("\\.",""); print $2}')/256)); o=$((o>=1024?o:0));  PN "Pageouts (MiB)"; s=( $(sar -u 1 10 | sed '$!d') ); [[ ${s[4]} -lt 90 ]] && o=$( printf 'User %s%%\t\tSystem %s%%' ${s[1]} ${s[3]} ) || o=; PR "Total CPU usage"; [[ "$o" ]] && o=$(ps acrx -o comm,ruid,%cpu | sed '2!d'); PR "Max %CPU by process (name, UID, %)"; o=$(kextstat -kl | grep -v com\\.apple | cut -c53- | cut -d\< -f1); PR "Loaded extrinsic kernel extensions"; o=$(launchctl list | sed 1d | awk '!/0x|com\.apple|org\.(x|openbsd)|\.[0-9]+$/{print $3}'); PR "Loaded extrinsic user agents"; o=$(launchctl getenv DYLD_INSERT_LIBRARIES); PR "Inserted libraries"; PC "cron configuration" /e*/cron*; o=$(crontab -l | grep [^[:blank:]]); PR "User cron tasks"; PC "Global launchd configuration" /e*/lau*; PC "Per-user launchd configuration" ~/.lau*; PF "Global login items" /L*/P*/loginw* Path; PF "Per-user login items" L*/P*/*loginit* Name; PF "Safari extensions" L*/Saf*/*/E*.plist Bundle | sed 's/\..*$//;s/-[1-9]$//'; o=$(find ~ $TMPDIR.. \( -flags +sappnd,schg,uappnd,uchg -o ! -user $UID -o ! -perm -600 \) | wc -l); PN "Restricted user files"; cd; o=$(find -L /S*/L*/E* {,/}L*/{A*d,Compon,Ex,In,Keyb,Mail/Bu,P*P,Qu,Scripti,Servi,Spo}* -type d -name Contents -prune | while read d; do ID=$($PB -c 'Print :CFBundleIdentifier' "$d/Info.plist") || ID=; ID=${ID:-No bundle ID}; egrep -qv "^com\.apple\.[^x]|Accusys|ArcMSR|ATTO|HDPro|HighPoint|driver\.stex|hp-fax|JMicron|microsoft\.MDI|print|SoftRAID" <<< $ID && printf '%s\n\t(%s)\n' "${d%/Contents}" "$ID"; done); PR "Extrinsic loadable bundles"; o=$(find /u*/{,*/}lib -type f -exec sh -c 'file -b "$1" | grep -qw shared && ! codesign -v "$1"' {} {} \; -print); PR "Unsigned shared libraries"; o=$(system_profiler SPFontsDataType | egrep "Valid: N|Duplicate: Y" | wc -l); PN "Font problems"; for d in {,/}L*/{La,Priv,Sta}*; do o=$(ls -A "$d"); PR "$d"; done; } 2> /dev/null | pbcopy; echo $'\nStep 1 done'
Copy the selected text to the Clipboard by pressing the key combination command-C. Then click anywhere in the Terminal window and paste (command-V). I've tested these instructions only with the Safari web browser. If you use another browser, you may have to press the return key after pasting.
The command may take up to a few minutes to run, depending on how many files you have and the speed of the computer.
Wait for the line "Step 1 done" to appear below what you entered.
The output of the command will be automatically copied to the Clipboard. All you have to do is paste into a reply to this message by pressing command-V again. Please don't copy anything from the Terminal window. No typing is involved in this step.
Step 2 
Remember that you must be logged in as an administrator for this step. Do as in Step 1 with this line:
PR () { [[ "$o" ]] && o=$(sed 's/^/   /' <<< "$o") && printf '\n%s:\n\n%s\n' "$1" "$o"; }; { o=$(sudo launchctl list | sed 1d | awk '!/0x|com\.(apple|openssh|vix\.cron)|org\.(amav|apac|calendarse|cups|dove|isc|ntp|post[fg]|x)/{print $3}'); PR "Loaded extrinsic daemons"; o=$(sudo defaults read com.apple.loginwindow LoginHook); PR "Login hook"; o=$(sudo crontab -l | grep [^[:blank:]]); PR "Root cron tasks"; o=$(syslog -k Sender kernel -k Message CReq 'GPU |hfs: Ru|I/O e|find tok|n Cause: -|NVDA\(|pagin|timed? ?o' | tail -n25 | awk '/:/{$4=""; print}'); PR "Log check"; } 2>&- | pbcopy; echo $'\nStep 2 done'
This time you'll be prompted for your login password, which you do have to type. Nothing will be displayed when you type it. Type it carefully and then press return. You may get a one-time warning to be careful. Heed that warning, but don't post it. If you see a message that your username "is not in the sudoers file," then you're not logged in as an administrator.
You can then quit Terminal.
In case of difficulty, please note:
☞ Steps 1 and 2 are all copy-and-paste — type only your login password when prompted.
☞ When you type your password, you won't see what you're typing.
☞ If you don’t have a password, set one before taking Step 2. If that’s not possible, skip the step.
☞ Step 2 might not produce any output, in which case the Clipboard will be empty. Step 1 will always produce something.
☞ The commands don't change anything, and merely running them will do neither good nor harm.
☞ Remember to post the output of both steps (unless you had to skip Step 2.) It's already in the Clipboard after you complete each step. You don't have to copy it. Just paste into a reply    
☞ If any personal information, such as your name or email address, appears in the output of either command, anonymize it before posting. Usually that won't be necessary.
☞ Don't post what you see in the Terminal window. The output is copied automatically to the Clipboard.
☞ Wait for the commands to finish before posting the output.
☞ Don't paste the output of Step 1 into the Terminal window. Paste it into a reply.