My Macbook keeps losing the desktop appearance and keyboard settings. How to fix this?

My Macbook Pro keeps losing the desktop appearance and keyboard settings randomly after going to sleep. They go back to default settings. I run the very last update of Snow Leopard.
How to fix this once and for all?

How do I cleanly disconnect.  I usually go to File, quit RDC.
someone told me that it could be my old macbook tying it up but most everything has been wiped off of that computer.

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