My macbook pro is now unworkably slow after hard drive replacement

installed a new harddrive wdc blue 320 5400, verified in DU, .  I reinstalled 10.5,
can't see time machine. and now it is so slow that it  rainbow spins for 30 seconds after each click on any window, folder, button, anything.
I've updated,activity monitored, mackeepered. 
my last ditch is migration assistant (now on 30th hours).
to see if a retored orignal system and prefs will see the Time Machine backup, and get back from there.
it will work fine if booted to a usb drive with same system.
if I didn't know better, Disk Utility is lying to me and this is a bad hard drive or somehow incompatible with the dual core intels.
is applejack worth trying, onyx?
I may just hit it with a banana
thanks to anyone with the know how about this.

thank you Neville that was alot of help.
I am faced with believing the few discussions concerning slow replacement drives, that claim,  that the new WD drives have firmware issues with the os x 10.5 2009 macbook pro's as well as any drive with a speed greater that 5400. all my utilies onyx & DU, say my drive is functioning.
however every operation that involves the new drive (whether it was the boot drive or not)  takes 30 -60 times  the speed I am used to.
I am now going to search for a confirmed compatible replacement drive.
p.s.
thanks for upgrading my thinking on drive set ups, that will hold me in good stead for years, and I appreciate that very much

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