My macbook pro when started has a white screen with flashing apple, file with question mark and stop signs...any ideas how to reboot it? command R doesn't work

Any help appreciated please.
After a while of being like this is turns off.

You may have to reset your MBP PRAM:
http://support.apple.com/kb/ht1379
The boot drive may need repair in Disk Utility>First Aid (verify and repair)
Critical system files may be damaged which will require that the OS may need to be reinstalled.
The connection to the boot drive is faulty.
The HDD has failed and needs to be replaced.
Ciao.

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