My mouse will not open any files or folders

My mouse will not open any files or folders.  I've had to do a hard reboot but nothing changes. The mouse will scroll across the screen but it will not left or right click on anything on my desktop

Hmmm, does the right button also not work?
One way to test is to Safe Boot from the HD, (holding Shift key down at bootup), run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions, Test for problem in Safe Mode...
PS. Safe boot may stay on the gray radian for a long time, let it go, it's trying to repair the Hard Drive
Reboot, test again.
If it only does it in Regular Boot, then it could be some hardware problem like Video card, (Quartz is turned off in Safe Mode), or Airport, or some USB or Firewire device, or 3rd party add-on, Check System Preferences>Accounts>Login Items window to see if it or something relevant is listed.
Check the System Preferences>Other Row, for 3rd party Pref Panes.
Also look in these if they exist, some are invisible...
/private/var/run/StartupItems
/Library/StartupItems
/System/Library/StartupItems
/System/Library/LaunchDaemons
/Library/LaunchDaemons

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    Process:         Preview [8995]
    Path:            /Applications/Preview.app/Contents/MacOS/Preview
    Identifier:      com.apple.Preview
    Version:         7.0 (826)
    Build Info:      Preview-826000000000000~2
    Code Type:       X86-64 (Native)
    Parent Process:  launchd [186]
    Responsible:     Preview [8995]
    User ID:         501
    Date/Time:       2013-12-05 04:41:17.157 -0500
    OS Version:      Mac OS X 10.9 (13A603)
    Report Version:  11
    Crashed Thread:  0  Dispatch queue: com.apple.main-thread
    Exception Type:  EXC_CRASH (SIGABRT)
    Exception Codes: 0x0000000000000000, 0x0000000000000000
    Application Specific Information:
    *** Terminating app due to uncaught exception 'NSUnknownKeyException', reason: '[<PVWindowController 0x7f9a0c028200> valueForUndefinedKey:]: this class is not key value coding-compliant for the key autoplayButtonPressedImage.'
    terminating with uncaught exception of type NSException
    abort() called
    Application Specific Backtrace 1:
    0   CoreFoundation                      0x00007fff93fa541c __exceptionPreprocess + 172
    1   libobjc.A.dylib                     0x00007fff980ade75 objc_exception_throw + 43
    2   CoreFoundation                      0x00007fff93fa4fc9 -[NSException raise] + 9
    3   Foundation                          0x00007fff9397c06e -[NSObject(NSKeyValueCoding) valueForUndefinedKey:] + 235
    4   Foundation                          0x00007fff93893406 -[NSObject(NSKeyValueCoding) valueForKey:] + 381
    5   Foundation                          0x00007fff938ab49f -[NSObject(NSKeyValueCoding) valueForKeyPath:] + 334
    6   AppKit                              0x00007fff8d93f26d -[NSBinder valueForBinding:resolveMarkersToPlaceholders:] + 160
    7   AppKit                              0x00007fff8d93eea9 -[NSObjectParameterBinder _updateObject:observedController:observedKeyPath:context:] + 1118
    8   AppKit                              0x00007fff8d935f68 -[NSObject(NSKeyValueBindingCreation) bind:toObject:withKeyPath:options:] + 652
    9   AppKit                              0x00007fff8d89ba94 -[NSIBObjectData nibInstantiateWithOwner:topLevelObjects:] + 1004
    10  AppKit                              0x00007fff8d8905fe loadNib + 327
    11  AppKit                              0x00007fff8d88fb9c +[NSBundle(NSNibLoading) _loadNibFile:nameTable:withZone:ownerBundle:] + 288
    12  AppKit                              0x00007fff8db245b2 +[NSBundle(NSNibLoading) loadNibFile:externalNameTable:withZone:] + 140
    13  AppKit                              0x00007fff8db243aa -[NSWindowController loadWindow] + 196
    14  AppKit                              0x00007fff8db29058 -[NSWindowController window] + 80
    15  Preview                             0x0000000103bc8070 Preview + 45168
    16  AppKit                              0x00007fff8db2a1b0 -[NSWindowController showWindow:] + 36
    17  Preview                             0x0000000103bc9541 Preview + 50497
    18  Foundation                          0x00007fff93895298 -[NSObject(NSThreadPerformAdditions) performSelector:onThread:withObject:waitUntilDone:modes:] + 871
    19  Foundation                          0x00007fff93894e6f -[NSObject(NSThreadPerformAdditions) performSelectorOnMainThread:withObject:waitUntilDone:] + 134
    20  Preview                             0x0000000103bc9483 Preview + 50307
    21  Preview                             0x0000000103bc82a4 Preview + 45732
    22  Preview                             0x0000000103ce06f5 Preview + 1193717
    23  libdispatch.dylib                   0x00007fff8d2561d7 _dispatch_call_block_and_release + 12
    24  libdispatch.dylib                   0x00007fff8d2532ad _dispatch_client_callout + 8
    25  libdispatch.dylib                   0x00007fff8d25af03 _dispatch_main_queue_callback_4CF + 333
    26  CoreFoundation                      0x00007fff93f0c839 __CFRUNLOOP_IS_SERVICING_THE_MAIN_DISPATCH_QUEUE__ + 9
    27  CoreFoundation                      0x00007fff93ec7b14 __CFRunLoopRun + 1636
    28  CoreFoundation                      0x00007fff93ec7275 CFRunLoopRunSpecific + 309
    29  HIToolbox                           0x00007fff91aa5f0d RunCurrentEventLoopInMode + 226
    30  HIToolbox                           0x00007fff91aa5cb7 ReceiveNextEventCommon + 479
    31  HIToolbox                           0x00007fff91aa5abc _BlockUntilNextEventMatchingListInModeWithFilter + 65
    32  AppKit                              0x00007fff8d8ad28e _DPSNextEvent + 1434
    33  AppKit                              0x00007fff8d8ac8db -[NSApplication nextEventMatchingMask:untilDate:inMode:dequeue:] + 122
    34  AppKit                              0x00007fff8d8a09cc -[NSApplication run] + 553
    35  AppKit                              0x00007fff8d88b803 NSApplicationMain + 940
    36  libdyld.dylib                       0x00007fff8e6265fd start + 1
    37  ???                                 0x0000000000000001 0x0 + 1
    Thread 0 Crashed:: Dispatch queue: com.apple.main-thread
    0   libsystem_kernel.dylib                  0x00007fff931df866 __pthread_kill + 10
    1   libsystem_pthread.dylib                 0x00007fff91e9d35c pthread_kill + 92
    2   libsystem_c.dylib                       0x00007fff8f810bba abort + 125
    3   libc++abi.dylib                         0x00007fff982fb141 abort_message + 257
    4   libc++abi.dylib                         0x00007fff98320abc default_terminate_handler() + 264
    5   libobjc.A.dylib                         0x00007fff980ae30d _objc_terminate() + 103
    6   libc++abi.dylib                         0x00007fff9831e3e1 std::__terminate(void (*)()) + 8
    7   libc++abi.dylib                         0x00007fff9831e456 std::terminate() + 54
    8   libobjc.A.dylib                         0x00007fff980ae0b0 objc_terminate + 9
    9   libdispatch.dylib                       0x00007fff8d2532c1 _dispatch_client_callout + 28
    10  libdispatch.dylib                       0x00007fff8d25af03 _dispatch_main_queue_callback_4CF + 333
    11  com.apple.CoreFoundation                0x00007fff93f0c839 __CFRUNLOOP_IS_SERVICING_THE_MAIN_DISPATCH_QUEUE__ + 9
    12  com.apple.CoreFoundation                0x00007fff93ec7b14 __CFRunLoopRun + 1636
    13  com.apple.CoreFoundation                0x00007fff93ec7275 CFRunLoopRunSpecific + 309
    14  com.apple.HIToolbox                     0x00007fff91aa5f0d RunCurrentEventLoopInMode + 226
    15  com.apple.HIToolbox                     0x00007fff91aa5cb7 ReceiveNextEventCommon + 479
    16  com.apple.HIToolbox                     0x00007fff91aa5abc _BlockUntilNextEventMatchingListInModeWithFilter + 65
    17  com.apple.AppKit                        0x00007fff8d8ad28e _DPSNextEvent + 1434
    18  com.apple.AppKit                        0x00007fff8d8ac8db -[NSApplication nextEventMatchingMask:untilDate:inMode:dequeue:] + 122
    19  com.apple.AppKit                        0x00007fff8d8a09cc -[NSApplication run] + 553
    20  com.apple.AppKit                        0x00007fff8d88b803 NSApplicationMain + 940
    21  libdyld.dylib                           0x00007fff8e6265fd start + 1
    Thread 1:
    0   libsystem_kernel.dylib                  0x00007fff931dfe6a __workq_kernreturn + 10
    1   libsystem_pthread.dylib                 0x00007fff91e9df08 _pthread_wqthread + 330
    2   libsystem_pthread.dylib                 0x00007fff91ea0fb9 start_wqthread + 13
    Thread 2:: Dispatch queue: com.apple.libdispatch-manager
    0   libsystem_kernel.dylib                  0x00007fff931e0662 kevent64 + 10
    1   libdispatch.dylib                       0x00007fff8d25543d _dispatch_mgr_invoke + 239
    2   libdispatch.dylib                       0x00007fff8d255152 _dispatch_mgr_thread + 52
    Thread 3:
    0   libsystem_kernel.dylib                  0x00007fff931dfe6a __workq_kernreturn + 10
    1   libsystem_pthread.dylib                 0x00007fff91e9df08 _pthread_wqthread + 330
    2   libsystem_pthread.dylib                 0x00007fff91ea0fb9 start_wqthread + 13
    Thread 4:
    0   libsystem_kernel.dylib                  0x00007fff931dfe6a __workq_kernreturn + 10
    1   libsystem_pthread.dylib                 0x00007fff91e9df08 _pthread_wqthread + 330
    2   libsystem_pthread.dylib                 0x00007fff91ea0fb9 start_wqthread + 13
    Thread 5:
    0   libsystem_kernel.dylib                  0x00007fff931dba1a mach_msg_trap + 10
    1   libsystem_kernel.dylib                  0x00007fff931dad18 mach_msg + 64
    2   com.apple.CoreFoundation                0x00007fff93ec8315 __CFRunLoopServiceMachPort + 181
    3   com.apple.CoreFoundation                0x00007fff93ec7939 __CFRunLoopRun + 1161
    4   com.apple.CoreFoundation                0x00007fff93ec7275 CFRunLoopRunSpecific + 309
    5   com.apple.AppKit                        0x00007fff8da4d1ce _NSEventThread + 144
    6   libsystem_pthread.dylib                 0x00007fff91e9c899 _pthread_body + 138
    7   libsystem_pthread.dylib                 0x00007fff91e9c72a _pthread_start + 137
    8   libsystem_pthread.dylib                 0x00007fff91ea0fc9 thread_start + 13
    Thread 0 crashed with X86 Thread State (64-bit):
      rax: 0x0000000000000000  rbx: 0x00007fff7d52d310  rcx: 0x00007fff5c040ea8  rdx: 0x0000000000000000
      rdi: 0x0000000000000707  rsi: 0x0000000000000006  rbp: 0x00007fff5c040ed0  rsp: 0x00007fff5c040ea8
       r8: 0x00007fff98321ab4   r9: 0x00007fff8f838900  r10: 0x0000000008000000  r11: 0x0000000000000206
      r12: 0x00007fff5c041030  r13: 0x000060800026b380  r14: 0x0000000000000006  r15: 0x00007fff5c040f10
      rip: 0x00007fff931df866  rfl: 0x0000000000000206  cr2: 0x000000010839b000
    Logical CPU:     0
    Error Code:      0x02000148
    Trap Number:     133
    Binary Images:
           0x103bbd000 -        0x103d9ffef  com.apple.Preview (7.0 - 826) <8B18FF0D-82EF-3898-B9B1-BEB43436F3B2> /Applications/Preview.app/Contents/MacOS/Preview
           0x103e50000 -        0x103e7bfff  com.apple.MediaUI (1.1 - 27) <2482C4A0-6D72-3870-AEF1-31F6015F2719> /System/Library/PrivateFrameworks/MediaUI.framework/Versions/A/MediaUI
           0x1082ab000 -        0x1082b6fff  libGPUSupport.dylib (9.0.83) <AF15BF74-F9B3-35B9-8728-3B3A2EB6E432> /System/Library/PrivateFrameworks/GPUSupport.framework/Versions/A/Libraries/lib GPUSupport.dylib
        0x123480000000 -     0x123480273fff  com.apple.ATIRadeonX2000GLDriver (8.18.27 - 8.1.8) <6AB347CE-5817-30AF-8DB6-A8A9B0F8F69E> /System/Library/Extensions/ATIRadeonX2000GLDriver.bundle/Contents/MacOS/ATIRade onX2000GLDriver
        0x7fff6d219000 -     0x7fff6d24c817  dyld (239.3) <D1DFCF3F-0B0C-332A-BCC0-87A851B570FF> /usr/lib/dyld
        0x7fff8c0cf000 -     0x7fff8c1fbfff  com.apple.MediaControlSender (1.9 - 190.4) <F5E934E1-D004-3C84-815A-961319F8C522> /System/Library/PrivateFrameworks/MediaControlSender.framework/Versions/A/Media ControlSender
        0x7fff8c1fe000 -     0x7fff8c286ff7  com.apple.CorePDF (4.0 - 4) <92D15ED1-D2E1-3ECB-93FF-42888219A99F> /System/Library/PrivateFrameworks/CorePDF.framework/Versions/A/CorePDF
        0x7fff8c290000 -     0x7fff8c2abff7  libPng.dylib (1038) <EF781AF8-C2E6-3179-B8A1-A584783070F1> /System/Library/Frameworks/ImageIO.framework/Versions/A/Resources/libPng.dylib
        0x7fff8c364000 -     0x7fff8c7b2fff  com.apple.VideoToolbox (1.0 - 1273.29) <6E38291D-7A81-3033-AFB9-61ABD38B6371> /System/Library/Frameworks/VideoToolbox.framework/Versions/A/VideoToolbox
        0x7fff8ca45000 -     0x7fff8ca53fff  com.apple.opengl (9.0.83 - 9.0.83) <AF467644-7B1D-327A-AC47-CECFCAF61990> /System/Library/Frameworks/OpenGL.framework/Versions/A/OpenGL
        0x7fff8d252000 -     0x7fff8d26cfff  libdispatch.dylib (339.1.9) <46878A5B-4248-3057-962C-6D4A235EEF31> /usr/lib/system/libdispatch.dylib
        0x7fff8d26d000 -     0x7fff8d2a5ff7  com.apple.RemoteViewServices (2.0 - 94) <3F34D630-3DDB-3411-BC28-A56A9B55EBDA> /System/Library/PrivateFrameworks/RemoteViewServices.framework/Versions/A/Remot eViewServices
        0x7fff8d2a6000 -     0x7fff8d2d7fff  com.apple.MediaKit (15 - 709) <23E33409-5C39-3F93-9E73-2B0E9EE8883E> /System/Library/PrivateFrameworks/MediaKit.framework/Versions/A/MediaKit
        0x7fff8d2d8000 -     0x7fff8d2ffff7  libsystem_network.dylib (241.3) <8B1E1F1D-A5CC-3BAE-8B1E-ABC84337A364> /usr/lib/system/libsystem_network.dylib
        0x7fff8d300000 -     0x7fff8d310ffb  libsasl2.2.dylib (170) <C8E25710-68B6-368A-BF3E-48EC7273177B> /usr/lib/libsasl2.2.dylib
        0x7fff8d311000 -     0x7fff8d32aff7  com.apple.Ubiquity (1.3 - 289) <C7F1B734-CE81-334D-BE41-8B20D95A1F9B> /System/Library/PrivateFrameworks/Ubiquity.framework/Versions/A/Ubiquity
        0x7fff8d32b000 -     0x7fff8d32efff  com.apple.AppleSystemInfo (3.0 - 3.0) <4D032152-AA40-350E-BB96-44BC55C5C69C> /System/Library/PrivateFrameworks/AppleSystemInfo.framework/Versions/A/AppleSys temInfo
        0x7fff8d32f000 -     0x7fff8d353ff7  libJPEG.dylib (1038) <86F349A8-882D-3326-A0B0-63257F68B1A7> /System/Library/Frameworks/ImageIO.framework/Versions/A/Resources/libJPEG.dylib
        0x7fff8d354000 -     0x7fff8d494fff  com.apple.QTKit (7.7.3 - 2826) <7A110F61-D4DD-3C84-950D-E5F486DE5765> /System/Library/Frameworks/QTKit.framework/Versions/A/QTKit
        0x7fff8d495000 -     0x7fff8d4d6fff  com.apple.PerformanceAnalysis (1.47 - 47) <784ED7B8-FAE4-36CE-8C76-B7D300316C9F> /System/Library/PrivateFrameworks/PerformanceAnalysis.framework/Versions/A/Perf ormanceAnalysis
        0x7fff8d575000 -     0x7fff8d65cff7  libxml2.2.dylib (26) <A1DADD11-89E5-3DE4-8802-07186225967F> /usr/lib/libxml2.2.dylib
        0x7fff8d6e4000 -     0x7fff8d6f0ff3  com.apple.AppleFSCompression (56 - 1.0) <5652B0D0-EB08-381F-B23A-6DCF96991FB5> /System/Library/PrivateFrameworks/AppleFSCompression.framework/Versions/A/Apple FSCompression
        0x7fff8d827000 -     0x7fff8d856ff5  com.apple.GSS (4.0 - 2.0) <ED98D992-CC14-39F3-9ABC-8D7F986487CC> /System/Library/Frameworks/GSS.framework/Versions/A/GSS
        0x7fff8d858000 -     0x7fff8d888fff  com.apple.IconServices (25 - 25.17) <4751127E-FBD5-3ED5-8510-08D4E4166EFE> /System/Library/PrivateFrameworks/IconServices.framework/Versions/A/IconService s
        0x7fff8d889000 -     0x7fff8e3fdff7  com.apple.AppKit (6.9 - 1265) <0E9FC8BF-DA3C-34C5-91CC-12BC922B5F01> /System/Library/Frameworks/AppKit.framework/Versions/C/AppKit
        0x7fff8e3fe000 -     0x7fff8e410ff7  com.apple.MultitouchSupport.framework (245.13 - 245.13) <D5E7416D-45AB-3690-86C6-CC4B5FCEA2D2> /System/Library/PrivateFrameworks/MultitouchSupport.framework/Versions/A/Multit ouchSupport
        0x7fff8e411000 -     0x7fff8e419fff  libsystem_dnssd.dylib (522.1.11) <270DCF6C-502D-389A-AA9F-DE4624A36FF7> /usr/lib/system/libsystem_dnssd.dylib
        0x7fff8e4af000 -     0x7fff8e615fff  libGLProgrammability.dylib (9.0.83) <9C97E814-F674-30F8-8C2D-C45FC1E7D934> /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libGLProgramma bility.dylib
        0x7fff8e616000 -     0x7fff8e622ff7  com.apple.OpenDirectory (10.9 - 173.1.1) <6B78BD7B-5622-38E6-8FC6-86A117E3ACCA> /System/Library/Frameworks/OpenDirectory.framework/Versions/A/OpenDirectory
        0x7fff8e623000 -     0x7fff8e626ff7  libdyld.dylib (239.3) <62F4D752-4089-31A8-8B73-B95A68893B3C> /usr/lib/system/libdyld.dylib
        0x7fff8e627000 -     0x7fff8e7dfff3  libicucore.A.dylib (511.25) <3ED7B656-416E-3071-AEC8-E85C90232F78> /usr/lib/libicucore.A.dylib
        0x7fff8e7e0000 -     0x7fff8eb78fff  com.apple.SceneKit (4.0 - 197) <1FEE4A1D-5B13-3774-8FE1-B79FD81CD1E5> /System/Library/Frameworks/SceneKit.framework/Versions/A/SceneKit
        0x7fff8eb79000 -     0x7fff8ec5dfff  com.apple.coreui (2.1 - 231) <432DB40C-6B7E-39C8-9FB5-B95917930056> /System/Library/PrivateFrameworks/CoreUI.framework/Versions/A/CoreUI
        0x7fff8ec5e000 -     0x7fff8f57a05f  com.apple.CoreGraphics (1.600.0 - 599.7) <7D0FD5A7-A061-39BA-8E00-723825D2C4DD> /System/Library/Frameworks/CoreGraphics.framework/Versions/A/CoreGraphics
        0x7fff8f57b000 -     0x7fff8f592fff  com.apple.CFOpenDirectory (10.9 - 173.1.1) <3FB4D5FE-860B-3BDE-BAE2-3531D919EF10> /System/Library/Frameworks/OpenDirectory.framework/Versions/A/Frameworks/CFOpen Directory.framework/Versions/A/CFOpenDirectory
        0x7fff8f593000 -     0x7fff8f5e5fff  libc++.1.dylib (120) <4F68DFC5-2077-39A8-A449-CAC5FDEE7BDE> /usr/lib/libc++.1.dylib
        0x7fff8f5e6000 -     0x7fff8f64cfff  com.apple.framework.CoreWiFi (2.0 - 200.21.1) <5491896D-78C5-30B6-96E9-D8DDECF3BE73> /System/Library/Frameworks/CoreWiFi.framework/Versions/A/CoreWiFi
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        0x7fff99cf9000 -     0x7fff99d00ff3  libcopyfile.dylib (103) <5A881779-D0D6-3029-B371-E3021C2DDA5E> /usr/lib/system/libcopyfile.dylib
    External Modification Summary:
      Calls made by other processes targeting this process:
        task_for_pid: 1
        thread_create: 0
        thread_set_state: 0
      Calls made by this process:
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        thread_create: 0
        thread_set_state: 0
      Calls made by all processes on this machine:
        task_for_pid: 65394
        thread_create: 0
        thread_set_state: 0
    VM Region Summary:
    ReadOnly portion of Libraries: Total=204.4M resident=85.2M(42%) swapped_out_or_unallocated=119.1M(58%)
    Writable regions: Total=78.3M written=3204K(4%) resident=7936K(10%) swapped_out=0K(0%) unallocated=70.5M(90%)
    REGION TYPE                      VIRTUAL
    ===========                      =======
    CG backing stores                   180K
    CG image                             40K
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    Foundation                            4K
    IOKit                               332K
    Kernel Alloc Once                     8K
    MALLOC                             49.5M
    MALLOC (admin)                       32K
    Memory Tag 242                       12K
    Memory Tag 251                       56K
    STACK GUARD                        56.0M
    Stack                              10.1M
    VM_ALLOCATE                        16.4M
    __DATA                             25.8M
    __IMAGE                             528K
    __LINKEDIT                         65.7M
    __TEXT                            138.7M
    __UNICODE                           544K
    mapped file                        46.8M
    shared memory                         4K
    ===========                      =======
    TOTAL                             412.4M

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