My Photoshop freezes and then won't open? Help?

Hi all,
I am running CS6, but over the past fe wmonths it has started acting strange.  When I go to save the file, sometimes as a PSD and other times as a jpeg or gif, the program freezes up on me and I get the spinning beachball.  I have to force quit the program and I loose all my progress.. which is a huge bummer.  After that I can't even open photoshop and I have to restart my computer.  The icon just bounces and bounces and then stops... so I have to restart.
Any ideas?  How can I fix this?
-jon

Sorry, I forgot to include that!  I'm runnign OSX 10.9.2, and I've got 580 gigs available on my 1TB internal hard drive.
And now, after my last restart, photoshop wont respond at all.  I click on the launch icon and it doesn't do anything... no bounce, no splash screen, etc... hmmmm

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