My programs are opening slowly, how do I get them to open quicker?

I have a Mac Pro 2 Ghz PowerPC Gr running OS 10.5.8.  I have been having difficulty with programs opening very slowly including Safari and Word which I use most frequently.  I have used ONYX to try to speed things up, have cleared the cache in Safari and it still seems to be slow responding when opening or closing programs.  What can I do to speed things up??  Thanks a lot!

How much free space on the startup disk?
Right or control click your MacintoshHD icon on your Desktop then click: Get Info
In the Get Info panel see: Capacity & Available.
Make sure there's a minimum of 15% disk space.
very slowly including Safari
From your Safari menu bar click Safari / Preferences then select the Security tab. Deselect: Enable plug ins Quit then relaunch Safari. If Safari opens faster, troubleshooting help here. Unsupported third-party add-ons may cause Safari to unexpectedly quit or have performance issues
Check Safari / Preferences - Extensions. If you have any installed, turn that off, quit, relaunch Safari.
Quit Safari. Open a Finder window select your Home folder in the Sidebar on the left. Then open the Library folder, then the Caches folder, then the com.apple.Safari folder. Move the cache.db file from the com.apple.Safari folder to the Trash. Relaunch Safari.
Check for Login Items:  Open System Preferences/Accounts then select the Login Items tab. Delete any files or apps you have listed there. And go to /Library/Startup Items. Move any files in the Startup Items folder to the Trash.
From the Safari menu bar click Safari / Reset Safari. Select the top 7 buttons, click Reset.
Try Safari in another user account. Same problems there, then log back into your admin account, launch Disk Utility.  /Applications/Utillities.
Select MacintoshHD in the panel on the left then select the First Aid tab.
Click: Verify Disk  (not Verify Disk Permissions). If the startup disk needs repairing, follow the instructions for Using Disk Utility to verify or repair disks
Since both Safari and Office open slower, could be corrupted or duplicate fonts.  Help here >Font problems and management in OS X | MacFixIt - CNET Reviews

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