My wife's mac is running really slow.  So slow that she can not run any software

The kernel is constantly running at 18% CPU utilization with no other software running
The OS 10.6.2
16 GB memory
So far I've disabled growl and time machine.  This had no affect.
I am seeing a fair number of malloc errors in the /var/log/system.log
Here is a clip from the system.log
ar 31 07:30:00 Elaine-Hoods-Mac-Pro com.apple.launchd.peruser.501[178] ([0x0-0xf00f].com.sk.eset.gui[222]): Job appears to have crashed: Segmentation fault
Mar 31 07:30:00 Elaine-Hoods-Mac-Pro ReportCrash[247]: Saved crash report for esets_gui[222] version ??? (4.0.52) to /Users/admin/Library/Logs/DiagnosticReports/esets_gui_2012-03-31-073000_Elaine- Hoods-Mac-Pro.crash
Mar 31 07:30:03 Elaine-Hoods-Mac-Pro SoftwareUpdateCheck[194]: PackageKit: *** Missing bundle identifier: /Library/Receipts/ScanGear MP150 202.pkg
Mar 31 07:31:50 Elaine-Hoods-Mac-Pro esets_daemon[91]: esets_daemon(91,0xb090b000) malloc: *** mmap(size=2262831104) failed (error code=12)\n*** error: can't allocate region\n*** set a breakpoint in malloc_error_break to debug
Mar 31 07:31:50 Elaine-Hoods-Mac-Pro esets_daemon[91]: error[005b0417]: Cannot allocate memory: Cannot allocate memory
Mar 31 07:31:50 Elaine-Hoods-Mac-Pro esets_daemon[90]: error[005a0000]: Child process esets_daemon[91] terminated with return code 71, restart in 0 seconds
Mar 31 07:33:02 Elaine-Hoods-Mac-Pro mds[47]: (/.Spotlight-V100/Store-V1/Stores/11E94AE7-CFC1-47B3-A840-09CCD2319114)(Warning ) IndexStore in setAttributes:Items's transaction id 94 is too low for the current index 95. Discarding oid 336ab3.
Mar 31 07:33:22 Elaine-Hoods-Mac-Pro netsession_mac[215]: netsession_mac(215,0xb038d000) malloc: *** auto malloc[215]: error: GC operation on unregistered thread. Thread registered implicitly. Break on auto_zone_thread_registration_error() to debug.
Mar 31 07:33:22 Elaine-Hoods-Mac-Pro com.akamai.single-user-client[215]: netsession_mac(215,0xb038d000) malloc: *** auto malloc[215]: error: GC operation on unregistered thread. Thread registered implicitly. Break on auto_zone_thread_registration_error() to debug.
It looks like the main culprit is the ESET anti-virus.
Should I remove it? 
thanks in advance
charles

Just as a follow up ESET is the problem

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