Need to reinstall osx due to possible virus/trojan infection

Hi guys,
I sometimes use my personal macbook in work, however ive been asked to remove it and reinstall osx as the computer centre have detected "some very nasty virus" of unknown name or origin. So i have a basic question if i reinstall osx using the disks will i have to completely delte and replace everything to get rid of the virus (am i safe to save my documents and programs to an external and drag them back after). Also ive read that clamav which i had downloaded some time ago is no use for protecting against trojans any suggestions of software which can?
thanks for your time
Conor

Do an Archive & Install installation, saving user and network settings. That should remove the said "unknown, nasty viurs", which I sincerely doubt has anything to do with your machine, but might be tagged to some Microsloth app macro. Details in http://support.apple.com/kb/HT1545

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