No audio or access to set AE preferences

I have no audio during playback in AE CS4.  Using RAM preview, audio is not muted within AE.  Entire program also tends to lock up.  Footage is HD.  Audio fine when running Final Cut.  Master files are QuickTime and AIF.  Unable to access preferences to check these settings, get this error message on all prefs: "After Effects error: getting volume info - disk error (I/O error; bad media) (-36).  (3 :: 89)"
This footage & project ran fine in my own Mac AE system, but I'm just getting familiar with this particular system:
OS 10.5.8 MacPro, 16GB RAM, 2.26GHz Quad-core, No OpenGL, both ATI Radeon HD 4870 & NVIDIA GeForce GT 120 installed (not sure which it's running through).  Ideas appreciated!

I had already run repair permissions to no avail.  There was a stream of incorrect permissions listed which did not change after the repair.  This is a system I'm using at a new job position, so I don't know its history.

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