No wake from sleep with upgrade to 10.10.3

Question

I recently upgraded a new iMac Retina 5K to Yosemite 10.10.3. Since the upgrade, the iMac will no longer wake from sleep. The screen remains black. I have to hold the power button for several seconds to reboot the machine. I am using the standard Bluetooth keyboard and Trackpad.
I have tried reseting the SMC, PRAM, and booting into Safe Mode (none of which fixed the problem). I know I can turn sleep off via Energy Saver, but my workflow makes using sleep a better option for me.
I looked in the system logs and find a dozen of the following messages after I try to wake from sleep:
Apr 12 12:10:12 iMac kernel[0]: **** [IOBluetoothHCIController][TransferACLPacketToHW] -- commandSleep(&mSystemOnTheWayWakingUp) failed -- counter = 1 ****
Apr 12 12:10:22 iMac kernel[0]: **** [IOBluetoothHCIController][TransferACLPacketToHW] -- commandSleep(&mSystemOnTheWayWakingUp) failed -- counter = 2 ****
Apr 12 12:10:32 iMac kernel[0]: **** [IOBluetoothHCIController][TransferACLPacketToHW] -- commandSleep(&mSystemOnTheWayWakingUp) failed -- counter = 3 ****
Apr 12 12:10:42 iMac kernel[0]: **** [IOBluetoothHCIController][TransferACLPacketToHW] -- commandSleep(&mSystemOnTheWayWakingUp) failed -- counter = 4 ****
Apr 12 12:10:52 iMac kernel[0]: **** [IOBluetoothHCIController][TransferACLPacketToHW] -- commandSleep(&mSystemOnTheWayWakingUp) failed -- counter = 5 ****
Apr 12 12:11:02 iMac kernel[0]: **** [IOBluetoothHCIController][TransferACLPacketToHW] -- commandSleep(&mSystemOnTheWayWakingUp) failed -- counter = 6 ****
Anyone know what the problem is and how to fix it?

Answer 1

Step 1
Take all the applicable steps in this support article. That's the starting point for any further efforts to solve the problem. Please read the whole article carefully and don't skip any of the steps, including the ones under the heading Additional troubleshooting. If you don't understand any of the steps, ask for guidance.
Also note that if you replaced the internal hard drive with an SSD, or if you're starting up from an external SSD, then that device may be causing the problem. Check the SSD manufacturer's website for a firmware update. The only solution may be to reinstall the original drive or avoid sleep altogether.
Step 2
If you're running OS X 10.8.5 or earlier, from the menu bar select
           ▹ System Preferences... ▹ Accessibility
If the checkbox at the bottom marked
          Enable access for assistive devices
is checked, uncheck it and test.
If you're running OS X 10.9 or later, select
           ▹ System Preferences... ▹ Security & Privacy ▹ Privacy ▹ Accessibility
If any applications are listed on the right and have a checked box next to them, uncheck all the boxes and test. You may first have to click the padlock icon in the lower left corner of the window and authenticate as an administrator to unlock the settings.
Step 3
In the Energy Saver pane of System Preferences, uncheck the box marked
          Put hard disks to sleep when possible
Step 4
If you don't already have a current backup, back up all data, then reinstall the OS.* You don't need to erase the startup volume, and you won't need the backup unless something goes wrong. If the system was upgraded from an older version of OS X, you may need the Apple ID and password you used.
If you installed the Java runtime distributed by Apple and still need it, you'll have to reinstall it. The same goes for Xcode. All other data will be preserved.
*The linked support article refers to OS X 10.10 ("Yosemite"), but the procedure is the same for OS X 10.7 ("Lion") and later.
Step 5
This and the next step must be taken as an administrator. If you have only one user account, you are the administrator.
Launch the Console application in any of the following ways:
☞ Enter the first few letters of its name into a Spotlight search. Select it in the results (it should be at the top.)
☞ In the Finder, select Go ▹ Utilities from the menu bar, or press the key combination shift-command-U. The application is in the folder that opens.
☞ Open LaunchPad and start typing the name.
In the Console window, select
          DIAGNOSTIC AND USAGE INFORMATION ▹ Diagnostic and Usage Messages
In the search box in the window's toolbar, enter "powerd" (without the quotes.)
You may see one or more lines like this:
com.apple.message.signature: Platform Failure
If you do see that, and you did everything in the preceeding steps, then you're dealing with an internal hardware fault. Make a "Genius" appointment at an Apple Store, or go to another authorized service provider.
Step 6
In the Console window, select
          DIAGNOSTIC AND USAGE INFORMATION ▹ System Diagnostic Reports
(not Diagnostic and Usage Messages) from the log list on the left. If you don't see that heading, select
          View ▹ Show Log List
from the menu bar.
There is a disclosure triangle to the left of the list item. If the triangle is pointing to the right, click it so that it points down.
You may see one or more reports with a name that begins with "Sleep Wake Failure" followed by a date. Select the most recent one. The contents of the report will appear on the right. Use copy and paste to post the entire contents—the text, not a screenshot.
I know the report is long, maybe several hundred lines. Please post all of it anyway.