Not possible to save InDesign document?

I'm working on a heavy InDesign document CS5, and now I can't save it. None of the options "Save" "Save As" or "Save a Copy" are possible to use.
I made a export for psf where I can see my latest changes, but when I asked a colleague to make a copy of the InDesign-file, none of my latest changes where there.
How can I save it now?

Thanks, I tried it, didn't work. Now I have closed it and re-made all my latest work : ) Better luck next time I guess....

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