Nothing happens when clicking on icons upon Startup

Hi all, I have a 2011 MBP 15" and when I boot the machine up sometimes I go to click Safari, iTunes, or whatever program and nothing happens.  This happens with both the track pad and my bluetooth mouse.  Sometimes that little colored beach ball will appear.  I have to then hard restart the machine.  Is this software or hardware related?  Are there any causes and solutions?  Any help would be great, thanks!

I'm having much the same problem with 4.1 on two different computers on completely different networks. The only thing they have in common is Win XP sp3.
It happens on various links all over the web i.e. nothing happens when I clink on the link. These links all work with V3.6.17 and I've tried all suggested fixes I could find so far.
Updated everything, deleted folders and reinstalled etc. but nothing works.
This browser is un-usable and HORRIBLE period.
Had to go back to V3.6.17 but couldn't get that from mozilla. This is some kind of sick joke. One that Firefox will pay dearly for.

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