NVIDIA QUADRO 4000 for MAC---Issues with Adobe Premeire

Hello,
Mac Pro (Tower)
*OS 10.7.5
*2.8 GHx Quad-Core Intel Xeon
*16 GB RAM
I've had a multitude of issues with Adobe Premiere on this system and I'm not sure what to attribute it to.  First of all: I have two MAC Book Pro's that run APremiere, with similiar specs and only 8GB of RAM.  These two laptops run APremiere flawlessly and it's because of this reason that I can deduce, that my 'tower' is having issues because of the NVIDIA QUADRO 4000 installed; it's the only difference, besides the RAM, that the computers have.  Has anyone had issues using the NVIDIA QUADRO 4000 before?  Some of the issues I've been having are (please note, these issues are random, happen at random times and on random projects.  The majority of the footage I use is MOV (from DSLR cameras) and MP4's (from a Sony EX-1)):
*Renders crashing
*Slow clip playback
*An oddity: certain MP4 files will go out of sync-on playback from APremiere and even in a VLC player
*AMedia Encoder crashes
Maybe the NVIDIA has nothing to do with it?
Thanks for your time and help.
Tim S.

Maybe the NVIDIA has nothing to do with it?
One way to accrue evidence would be to turn off Mercury Playback in the Project Settings.
I have that card, and turning of MPE often gets me through a session.  Some here have claimed that the card is the cause of the frequent Serious Errors, and disabling it is the solution.
That's hardly satisfactory when one of the best features of Pr is the ability to use CUDA.
However, anything going through the card also has to pass through Pr and the OS.  Adobe claims that updating to 10.8 fixes some bugs, but according to some here (myself included), not enough.
I had one project recently that I couldn't get the Serious Errors to stop until I re-installed the nVidia driver.
But, your list of problems could be due to corrupt Pr preferences.  If you have a Mac, you need to get used to refreshing your prefs several times a day.  They could also be corrupt media.  That will cause renders to crash.

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       Shaders 444: 1
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